Association between psychiatric disorders and glioma risk: evidence from Mendelian randomization analysis

BMC Cancer

Table 2 Sensitivity analyses including weighted median estimator, MR-Egger regression, Cochran’s Q statistic and MR-Egger intercept test for the causal association between glioma and psychiatric disorders

			Weighted median estimator				MR-Egger				Heterogeneity (P)	Pleiotropy (P)
Exposure	Outcome	SNPs	P	OR	Lower 95%CI	Upper 95%CI	P	OR	Lower 95%CI	Upper 95%CI	Heterogeneity (P)	Pleiotropy (P)
all-glioma	PD	42	0.631	0.957	0.800	1.144	0.621	1.099	0.758	1.596	0.819	0.542
	ASD	39	0.709	1.013	0.946	1.084	0.778	1.022	0.882	1.183	0.567	0.846
	SCZ	42	0.075	1.044	0.996	1.095	0.002^**	1.235	1.088	1.404	0.000^**	0.007^**
	BD	42	0.994	1.000	0.950	1.054	0.319	1.077	0.932	1.245	0.000^**	0.351
	MDD	38	0.761	1.003	0.982	1.025	0.125	1.038	0.991	1.087	0.361	0.078
GBM	PD	32	0.028	1.198	1.019	1.408	0.168	1.249	0.918	1.700	0.226	0.322
	ASD	32	0.555	1.018	0.960	1.079	0.469	1.040	0.937	1.154	0.878	0.921
	SCZ	32	0.644	1.009	0.971	1.048	0.547	1.024	0.948	1.106	0.146	0.564
	BD	32	0.220	1.029	0.983	1.078	0.788	0.987	0.899	1.084	0.013^*	0.760
	MDD	32	0.572	1.005	0.987	1.025	0.524	1.011	0.978	1.044	0.450	0.879
non-GBM	PD	42	0.688	0.973	0.851	1.111	0.895	1.020	0.765	1.358	0.902	0.744
	ASD	40	0.774	1.008	0.953	1.067	0.292	1.078	0.939	1.238	0.002^**	0.366
	SCZ	42	0.261	1.019	0.986	1.053	0.200	1.054	0.974	1.142	0.029^*	0.380
	BD	42	0.007^**	0.951	0.916	0.987	0.693	0.983	0.901	1.072	0.024^*	0.782
	MDD	37	0.454	0.994	0.978	1.010	0.616	0.991	0.959	1.025	0.321	0.902

PD = panic disorder, ASD = autism spectrum disorder, SCZ = schizophrenia, BD = bipolar disorder, MDD = major depressive disorder
* Showed significant differences P < 0.05, ** Bonferroni corrected P < 0.01
Heterogeneity was examined by using Cochran’s Q statistic
Pleiotropy was assessed with MR-Egger intercept test

ISSN: 1471-2407