Association between psychiatric disorders and glioma risk: evidence from Mendelian randomization analysis

BMC Cancer

Table 1 Sensitivity analyses including weighted median estimator, MR-Egger regression, Cochran’s Q statistic and MR-Egger intercept test for the causal association between psychiatric disorders and glioma

			Weighted median estimator				MR-Egger				Heterogeneity (P)	Pleiotropy (P)
Exposure	Outcome	SNPs	P	OR	Lower 95%CI	Upper 95%CI	P	OR	Lower 95%CI	Upper 95%CI	Heterogeneity (P)	Pleiotropy (P)
PD	all-glioma	8	0.465	1.042	0.935	1.160	0.750	0.940	0.651	1.357	0.208	0.750
ASD		30	0.432	1.059	0.918	1.222	0.949	0.991	0.746	1.316	0.527	0.541
SCZ		128	0.106	1.071	0.985	1.165	0.137	1.203	0.945	1.533	0.054	0.333
BD		46	0.298	0.933	0.820	1.063	0.124	1.497	0.904	2.478	0.133	0.084
MDD		65	0.266	0.854	0.648	1.127	0.035^*	3.121	1.106	8.807	0.776	0.029^*
PD	GBM	8	0.347	0.936	0.816	1.073	0.589	0.868	0.533	1.412	0.105	0.560
ASD		30	0.356	1.083	0.915	1.281	0.678	1.077	0.762	1.523	0.665	0.933
SCZ		128	0.997	1.000	0.906	1.103	0.728	1.050	0.799	1.380	0.396	0.931
BD		46	0.735	1.029	0.873	1.213	0.095	1.699	0.924	3.123	0.149	0.064
MDD		65	0.739	0.945	0.676	1.320	0.0996	2.948	0.829	10.48	0.854	0.078
PD	non-GBM	8	0.730	0.977	0.854	1.114	0.969	0.992	0.674	1.459	0.625	0.983
ASD		29	0.994	0.999	0.833	1.198	0.522	0.876	0.587	1.307	0.528	0.460
SCZ		128	0.009^**	1.160	1.039	1.296	0.069	1.402	0.977	2.013	0.000^**	0.223
BD		46	0.608	0.954	0.795	1.144	0.287	1.482	0.724	3.031	0.043^*	0.223
MDD		65	0.295	0.817	0.561	1.192	0.041^*	4.567	1.099	18.976	0.203	0.040^*

PD = panic disorder, ASD = autism spectrum disorder, SCZ = schizophrenia, BD = bipolar disorder, MDD = major depressive disorder
* Showed significant differences P < 0.05, ** Bonferroni corrected P < 0.01
Heterogeneity was examined by using Cochran’s Q statistic
Pleiotropy was assessed with MR-Egger intercept test

ISSN: 1471-2407