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Fig. 5 | BMC Cancer

Fig. 5

From: Cancer-associated fibroblast-derived extracellular vesicles promote lymph node metastases in oral cavity squamous cell carcinoma by encapsulating ITGB1 and BMI1

Fig. 5

Knockdown of BMI1 and ITGB1 abates the tumor-promoting and metastasis-promoting properties of OCSCC cells in vivo. A The weight and volume of tumors formed by SCC-25 cells treated with BMI1 or ITGB1 knockdown (n = 6). B Ki67 expression in tumors determined by immunohistochemistry (n = 6). C The weight and volume of lymph nodes in mice induced with in vivo orthotopic xenograft model (n = 6). D Distribution of SCC-25 in lymph nodes observed by HE staining (n = 6). E Determination of Ki67 expression in lymph nodes by immunohistochemistry (n = 6). One-way or two-way ANOVA. Data are presented as means ± SD (*p <.05)

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BMC Cancer

ISSN: 1471-2407

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