Skip to main content
Fig. 4 | BMC Cancer

Fig. 4

From: Cancer-associated fibroblast-derived extracellular vesicles promote lymph node metastases in oral cavity squamous cell carcinoma by encapsulating ITGB1 and BMI1

Fig. 4

Knockdown of BMI1 and ITGB1 abates the promoting effects of CAF-EVs on OCSCC cells. A The expression of BMI1 and ITGB1 in OCSCC cells with BMI1 or ITGB1 knockdown was measured using RT-qPCR. B The wound healing rate of OCSCC cells with BMI1 or ITGB1 knockdown was determined using a wound healing assay. C The effect of BMI1 or ITGB1 knockdown on the migration and invasion of OCSCC cells. D The effect of BMI1 or ITGB1 knockdown on the proliferative capacity of OCSCC cells measured using EdU proliferation assay. E The effect of BMI1 or ITGB1 knockdown on the colony-forming ability of OCSCC cells was measured using colony formation assay. Two-way ANOVA. Data are presented as means ± SD. Results are representative of at least three independent experiments (*p <.05)

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us