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Fig. 1 | BMC Cancer

Fig. 1

From: Cancer-associated fibroblast-derived extracellular vesicles promote lymph node metastases in oral cavity squamous cell carcinoma by encapsulating ITGB1 and BMI1

Fig. 1

Characterization and effects of CAF-EVs. A Vimentin, FAP, and α-SMA protein expression in NF and CAF was examined using western blot analysis. B The morphology of CAF-EVs observed under a TEM. C The diameter size of CAF-EVs was analyzed using NTA. D CD81, TSG101, FLOT1, ALIX, and Calnexin in CAF and derived CAF-EVs were detected using western blot analysis. E The uptake of Dil-labeled CAF-EVs by OCSCC cells. F The effect of CAF-EVs on the proliferative capacity of OCSCC cells was measured using an EdU proliferation assay. G The effect of CAF-EVs on the colony-forming ability of OCSCC cells was measured using colony formation assays. H The wound healing rate of OCSCC cells before and after CAF-EVs treatment was determined using a wound healing assay. I The effect of CAF-EVs on the migration and invasion of OCSCC cells. Two-way ANOVA. Data are presented as means ± SD. Results are representative of at least three independent experiments (*p <.05)

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BMC Cancer

ISSN: 1471-2407

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