Table 1 Patient and tumor characteristics at baseline, total and by study site
Total | Site 1 | Site 2 | ||||||
|---|---|---|---|---|---|---|---|---|
Count | % | Count | % | Count | % | p-value* | ||
Number of patients (NB! Row percent) | 586 | 395 | 67.4% | 191 | 32.6% | |||
Age at diagnosis, years | Mean (range) | 65 (29—91) | 64 (30—91) | 65 (29—90) | 0.451 | |||
BMI | Mean (range) | 26.8 (16.7—48.9) | 27.2 (16.7—48.9) | 26.2 (18.8—42.9) | 0.020 | |||
Missing | 50 | 49 | 1 | |||||
Postmenopausal | No | 85 | 15.4% | 55 | 14.9% | 30 | 16.5% | 0.620 |
Yes | 467 | 84.6% | 315 | 85.1% | 152 | 83.5% | ||
Missing | 34 | 25 | 9 | |||||
Screening detected | No | 240 | 41.0% | 155 | 39.2% | 85 | 44.5% | 0.225 |
Yes | 346 | 59.0% | 240 | 60.8% | 106 | 55.5% | ||
Bilateral cancer | No | 553 | 94.4% | 379 | 95.9% | 174 | 91.1% | 0.017 |
Yes | 33 | 5.6% | 16 | 4.1% | 17 | 8.9% | ||
Multifocal cancer (mammography) | No | 531 | 91.1% | 359 | 91.1% | 172 | 91.0% | 0.965 |
Yes | 52 | 8.9% | 35 | 8.9% | 17 | 9.0% | ||
Missinga | 3 | 1 | 2 | |||||
Largest tumor (long axis, mm, mammography) | Mean (range) | 19 (3–110) | 17 (3–110) | 22 (5–90) | < 0.001 | |||
Missinga | 55 | 30 | 25 | |||||
Centrally positioned tumor (mammography, sub areolar or within 2 cm of the mammilla) | No | 383 | 87.4% | 251 | 88.1% | 132 | 86.3% | 0.589 |
Yes | 55 | 12.6% | 34 | 11.9% | 21 | 13.7% | ||
Missinga | 148 | 110 | 38 | |||||
ER status CNB | Negative (< 1%) | 24 | 7.3% | 20 | 9.4% | 4 | 3.4% | 0.048 |
Positive (≥ 1%) | 305 | 92.7% | 193 | 90.6% | 112 | 96.6% | ||
Missing | 257 | 182 | 75 | |||||
PR status CNB | Negative (< 1%) | 57 | 18.0% | 40 | 19.3% | 17 | 15.6% | 0.413 |
Positive (≥ 1%) | 259 | 82.0% | 167 | 80.7% | 92 | 84.4% | ||
Missing | 270 | 188 | 82 | |||||
HER2 status CNB | Negative | 296 | 95.2% | 194 | 94.6% | 102 | 96.2% | 0.534 |
Positive | 15 | 4.8% | 11 | 5.4% | 4 | 3.8% | ||
Missing | 275 | 190 | 85 | |||||
Proliferation index Ki67 (%) CNB | Mean (range) | 26.6 (1.0—95.0) | 28.4 (3.0—95.0) | 23.1 (1.0—83.0) | 0.016 | |||
Missing | 274 | 189 | 85 | |||||
Complete cases ER/PR/Ki67 CNB | No | 274 | 46.8% | 189 | 47.8% | 85 | 44.5% | 0.453 |
Yes | 312 | 53.2% | 206 | 52.2% | 106 | 55.5% | ||
Vascular invasion CNB (only reported when present) | Yes | 4 | 4 | 0 | - | |||
Missing | 582 | 391 | 191 | |||||
Histopathological type CNB | NST (No specific type, ductal) | 445 | 75.9% | 301 | 76.2% | 144 | 75.4% | 0.705 |
Lobular | 105 | 17.9% | 72 | 18.2% | 33 | 17.3% | ||
Other | 36 | 6.2% | 22 | 5.6% | 14 | 7.3% | ||