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Table 3 Univariate and multivariate analysis of the risk factors in EBC* with the high nodal burden group

From: Diagnostic value of applying preoperative breast ultrasound and clinicopathologic features to predict axillary lymph node burden in early invasive breast cancer: a study of 1247 patients

Variables

Univariate analysis

 

Multivariate analysis

 

P

OR(95%CI)

 

P

OR(95%CI)

MD

< 0.001

0.076(1.029,1.057)

 

< 0.001

1.043(1.028,1.058)

 Ki-67

0.006

1.565(1.134,2.159)

 

0.760

1.121(0.539,2.333)

MS

     

 Luminal A

Ref

Ref

   

 Luminal B

0.001

1.808(1.259,2.595)

 

0.796

1.133(0.495,2.503)

 Her-2 overexpression

0.125

1.506(0.893,2.541)

 

0.073

0.431(0.172,1.081)

 TN

0.325

1.285(0.779,2.120)

 

0.787

1.121(0.491,2.555)

 Hyperechoic halo

< 0.001

2.233(1.653,3.017)

 

< 0.001

2.546(1.774,3.655)

 Posterior features

     

 No features

Ref

Ref

   

 Enhancement

< 0.001

0.164(0.060,0.451)

 

0.002

0.193(0.069,0.542)

 Shadowing

0.004

2.181(1.289,3.690)

 

0.007

2.155(1.234,3.762)

 Combined pattern

0.073

0.427(0.168,1.084)

 

0.123

0.464(0.175,1.233)

 Shape

0.003

2.892(1.443,5.796)

 

0.018

2.422 (1.167,5.025)

 Axillary US

< 0.001

0.188(1.213,2.207)

 

0.031

1.418(1.032,1.949)

  1. EBC Early-stage breast cancer, ER Estrogen-receptor, PR Progesterone-receptor, HER-2 Human epidermal growth factor receptor 2, MS Molecular subtype, TN Triple negative,US ultrasound