Table 2 PD-L1 expression and TMB status in RET fusion positive patients
Total RET-fusion positive | Immunophenotyped cohort | ICI treatment cohort | P-value | |
|---|---|---|---|---|
PD-L1 expression TPS (%) | N = 129 | N = 101 | n = 28 | 0.07 |
Negative (< 1) | 66 (51.2) | 53 (52.5) | 13 (25.0) | |
low (1–49) | 40 (31.0) | 32 (31.7) | 8 (25.0 | |
High (≥ 50) | 23 (17.8) | 16 (15.8) | 7 (50.0) | |
PD-L1 expression TPS (%) median | 0 | 0 | 30 | 0.08 |
TMB (mut/Mb) | N = 35 | N = 27 | n = 8 | 0.28 |
Low (< 5) | 22 (62.9) | 18 (66.7) | 4 (50) | |
Intermediate (5–10) | 8 (22.9) | 4 (14.8) | 4 (50) | |
High (≥ 10) | 5 (14.3) | 5 (18.5) | 0 (0) | |
TMB (mut/Mb) | 0.005 | |||
Median (range) | 3.99 (1.0-12.7) | 3.1 (1.0-12.7) | 5.3 (3.5–7.01) | |