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Table 1 Phenotypic characteristics and NGS results of patients included for fecal metagenomics and WGS

From: Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients

ID

#Ad

Ad age range first

CRC age range first

#SBS88/ID18

#tested

%

Feces

WGS

1

22

66–70

41–45

2

7

28.6

Y

Y

2

> 9

66–70

66–70

3

3

100.0

Y

Y

3

15

46–50

46–50

6

7

85.7

Y

N

4

13

66–70

66–70

3

9

33.3

Y

Y

5

70

66–70

66–70

3

10

30.0

N

Y

6

4

61–65

61–65

3

6

50.0

Y

Y

7

18

56–60

-

0

4

0.0

Y

Y

8

10

51–55

51–55

3

4

75.0

Y

Y

9

2

51–55

51–55

2

4

50.0

Y

Y

10

10

51–55

-

8

10

80.0

Y

Y

11

28

81–85

-

2

6

33.3

Y

N

12

36

71–75

-

2

4

50.0

N

Y

13

27

61–65

61–65

2

3

66.7

Y

Y

14

3

21–25

-

3

3

100.0

Y

Y

15

10

51–55

-

2

6

33.3

Y

Y

16

11

51–55

-

2

3

66.7

Y

Y

17

22

66–70

-

2

4

50.0

Y

Y

18

14

61–65

-

2

6

33.3

Y

Y

19

24

41–45

-

2

4

50.0

N

Y

20

10

56–60

-

2

4

50.0

Y

Y

21

18

46–50

-

0

4

0.0

Y

Y

22

18

61–65

-

0

4

0.0

Y

Y

23

20

61–65

-

0

3

0.0

Y

Y

24

14

46–50

-

0

4

0.0

Y

Y

25

10

46–50

46–50

4

4

100.0

Y

Y

26

8

46–50

46–50

0

4

0.0

Y

Y

27

4

21–25

21–25

0

4

0.0

N

Y

28

2

61–65

61–65

0

3

0.0

Y

Y

29

9

61–65

61–65

0

5

0.0

Y

Y

  1. #Ad– numbers of colorectal adenomas developed, Ad age first– age first colorectal adenoma diagnosis, CRC age first– age of colorectal carcinoma diagnosis, #SBS88/ID18– number of adenomas or carcinomas with a variant fitting SBS88 or ID18 based on NGS, Tested– Total number of adenomas or carcinomas tested using NGS, % - percentage of adenomas or carcinomas with a colibactin-associated variant, Feces– fecal metagenomics performed yes or no, WGS– WGS performed yes or no