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Table 2 Patient characteristics and outcome

From: Clinical activity and safety of sintilimab, bevacizumab, and TMZ in patients with recurrent glioblastoma

No.

Gender

History

PRS-type

Prior therapy

Dose of bevacizumab

Dose of TMZ

Dose of Sintilimab

Using period

Best response

PFS(months)

DOR(months)

1

M

GBM

Primary

Surgery

200(3)

500(2)

160

200

5

PR

3.29

1.84

2

M

GBM

secondary

NA

500

240

200

4

PR

2.70

1.27

3

M

GBM

Primary

Bevacizumab

500

300

200

8

PR

6.10

5.16

4

F

GBM

Primary

Bevacizumab

600

300

200

4

SD

4.10

 

5

M

GBM

Primary

GNC−039

500

300

200

7

SD

5.10

 

6

F

GBM

Primary

NA

500

260

200

10

PR

8.52+

6.57+

7

F

GBM

Primary

GNC−039

500

240

200

5

PR

3.34

1.58

8

F

GBM

secondary

NA

600

240

200

3

PD

1.45

 
  1. Abbreviations: TMZ Temozolomide, PR Partial response, SD Stable disease, PD Progressive disease, mPFS Median progression-free survival, ORR Overall response rate, DOR Duration of Response
  2. No.1 patient was on 200 mg bevacizumab for the first three cycles, and due to worsening clinical symptoms, the dose was increased to 500 mg for the last two cycles