Table 3 Distribution and comparisons of AML patients with or without cardiac injury in the training set, testing set and external validation set

Gender

0.652

0.708

0.393

 Male

63(55.8)

88(53.0)

25(52.1)

40(55.6)

29(60.4)

27(51.9)

 Female

50(44.2)

78(47.0)

23(47.9)

32(44.4)

19(39.6)

25(48.1)

Age (years)

0.159

0.764

0.030

 Age < 60

55(48.7)

95(57.2)

28(58.3)

40(55.6)

21(43.8)

34(65.4)

 Age ≥ 60

58(51.3)

71(42.8)

20(41.7)

32(44.4)

27(56.2)

18(34.6)

Smoking history

20(17.7)

27(16.3)

0.753

7(14.6)

13(18.1)

0.617

14(29.2)

10(19.2)

0.245

History of hypertension

21(18.6)

26(15.7)

0.522

7(14.6)

13(18.1)

0.617

9(18.8)

6(11.5)

0.313

History of diabetes

13(11.5)

8(4.8)

0.038

3(6.2)

5(6.9)

1.000

6(12.5)

3(5.8)

0.409

WBC (10⁹/L)

27.56(6.53-76.505)

5.52(1.7675–16.065)

< 0.001

21.205(5.0675–86.14)

4.6950(1.6375–14.2175)

< 0.001

28.115(3.77-64.7125)

4.315(1.9-23.7675)

0.011

RBC (10¹²/L)

2.32(1.83–2.88)

2.14(1.6325-2.56)

0.018

2.295(1.84-2.8575)

2.07(1.655-2.5)

0.033

2.385(1.8075–2.945)

2.23(1.7975-2.56)

0.210

Hb (g/L)

70(58.65-87)

69.85(54.75-85.425)

0.331

70.85(59.775–90.375)

68.8(54.375–82.95)

0.263

78.4(61-88.7)

72.2(58.775–88.5)

0.558

PLT (10⁹/L)

31(17.5–70)

38(22-72.25)

0.357

39(22-89.5)

43.5(20.25-73)

0.682

29.5(22.25-96)

37.5(23.25–71.5)

0.959

BM blast ratio (%)

65.2(37.95–83.75)

56.15(31.875–77.35)

0.015

59.75(34.825-83)

57.75(36.625–72.875)

0.247

65.75(48.47-85.6675)

62.25(24.7775-79)

0.013

Gene mutations

 NPM1

29(25.7)

14(8.4)

< 0.001

13(27.1)

7(9.7)

0.012

14(29.2)

9(17.3)

0.159

 CEBPA

13(11.5)

18(10.8)

0.863

4(8.3)

7(9.7)

1.000

10(20.8)

7(13.5)

0.327

 FLT3

30(26.5)

17(10.2)

< 0.001

13(27.1)

7(9.7)

0.012

16(33.3)

9(17.3)

0.064

 C-kit

7(6.2)

5(3.0)

0.324

2(4.2)

1(1.4)

0.720

4(8.3)

5(9.6)

1.000

 TP53

8(7.1)

9(5.4)

0.570

4(8.3)

3(4.2)

0.578

5(10.4)

2(3.8)

0.371

 RUNX1

4(3.5)

7(4.2)

1.000

3(6.2)

3(4.2)

0.932

4(8.3)

3(5.8)

0.913

 Ras

10(8.8)

6(3.6)

0.065

3(6.2)

1(1.4)

0.350

5(10.4)

5(9.6)

1.000

 TET2

7(6.2)

9(5.4)

0.785

7(14.6)

3(4.2)

0.092

7(14.6)

4(7.7)

0.271

 IDH

12(10.6)

13(7.8)

0.423

6(12.5)

6(8.3)

0.664

5(10.4)

4(7.7)

0.900

 WT1

77(68.1)

88(53.0)

0.012

32(66.7)

38(52.8)

0.131

22(45.8)

22(42.3)

0.723

 JAK2

5(4.4)

1(0.6)

0.082

5(10.4)

0(0)

0.020

3(6.2)

1(1.9)

0.554

 AML1-ETO

9(8.0)

10(6.0)

0.528

5(10.4)

5(6.9)

0.736

5(10.4)

0(0)

0.054

 CBFB-MYH11

5(4.4)

8(4.8)

0.878

1(2.1)

3(4.2)

0.917

2(4.2)

4(7.7)

0.749

 BCR-ABL

5(4.4)

4(2.4)

0.555

4(8.3)

1(1.4)

0.162

1(2.1)

2(3.8)

1.000

 MLL

5(4.4)

9(5.4)

0.708

3(6.2)

6(8.3)

0.944

2(4.2)

2(3.8)

1.000

Cytogenetics

Abnormal karyotype

66(58.4)

83(50.0)

0.167

26(54.2)

34(47.2)

0.456

31(64.6)

29(55.8)

0.369

Complex karyotype

16(14.2)

28(16.9)

0.542

10(20.8)

17(23.6)

0.721

9(18.8)

7(13.5)

0.471

Monosomy karyotype

11(9.7)

17(10.2)

0.890

5(10.4)

11(15.3)

0.443

7(14.6)

3(5.8)

0.257

 t8-21

8(7.1)

7(4.2)

0.298

5(10.4)

3(4.2)

0.331

2(4.2)

0(0)

0.228

 inv16

5(4.4)

7(4.2)

1.000

1(2.1)

2(2.8)

1.000

3(6.2)

4(7.7)

1.000

 t9-22

2(1.8)

2(1.2)

1.000

1(2.1)

0(0)

0.400

1(2.1)

2(3.8)

1.000

 plus8

10(8.8)

15(9.0)

0.957

6(12.5)

7(9.7)

0.631

4(8.3)

2(3.8)

0.601

 del5q

11(9.7)

11(6.6)

0.344

3(6.2)

4(5.6)

1.000

5(10.4)

2(3.8)

0.371

 del7

7(6.2)

10(6.0)

0.953

2(4.2)

6(8.3)

0.601

4(8.3)

3(5.8)

0.913

 del17p

3(2.7)

6(3.6)

0.920

3(6.2)

2(2.8)

0.641

2(4.2)

3(5.8)

1.000

Abnormal NT-proBNP

41(36.3)

29(17.5)

< 0.001

17(35.4)

14(19.4)

0.050

21(43.8)

5(9.6)

< 0.001

Echocardiogram indexes

LA (mm)

34(31–38)

33(29–38)

0.459

34.5(31.25-37)

34(30–38)

0.588

35.5(31–38)

33(29–39)

0.445

LV (mm)

45(43–48)

45(42–48)

0.700

46(41.5–48)

46(42.25-48)

0.778

43.5(38.25-49)

45(41–48)

0.663

IVS (mm)

10(9–11)

10(9–11)

0.070

10(9.25-12)

10(9–11)

0.125

10(9–12)

10(9–11)

0.371

EDV (ml)

95(83-107.5)

97(78–118)

0.471

93.5(78-110.5)

99(83–118)

0.314

101.5(87-118.25)

100(88-108.75)

0.942

ESV (ml)

32(25–41)

30(25–39)

0.404

30.5(22–44)

30(25–39)

0.271

35(28-43.25)

31(25.25-39)

0.168

SV (ml)

64(53–73)

67(55–80)

0.151

68.5(56-77.75)

67.5(56.75–82.25)

0.799

68(56.25-78)

68(55.5–79)

0.855

EF (%)

63(60–69)

66.5(60–70)

0.045

64.5(60–71)

66(59.25–71.75)

0.674

60(57–66)

65(61.25–70.75)

< 0.001