The role of adenocarcinoma subtypes and immunohistochemistry in predicting lymph node metastasis in early invasive lung adenocarcinoma

Xue, Mengchao; Liu, Junjie; Li, Zhenyi; Lu, Ming; Zhang, Huiying; Liu, Wen; Tian, Hui

doi:10.1186/s12885-024-11843-4

Table 3 Univariate and multivariate logistic regression analysis of LNM factors in a training cohort

From: The role of adenocarcinoma subtypes and immunohistochemistry in predicting lymph node metastasis in early invasive lung adenocarcinoma

Characteristics	Univariate analysis		Multivariate analysis
Characteristics	OR (95%CI)	P	OR (95%CI)	P
Age	0.959 (0.927, 0.991)	0.013	0.934 (0.871, 0.996)	< 0.001
SA	1.041 (1.003, 1.081)	0.033	1.025 (0.937, 1.109)	0.008
CA125	1.045 (1.006, 1.094)	0.028	1.103 (1.021, 1.189)	0.042
Mucinous
No	Ref	Ref	Ref	Ref
Yes	2.527 (1.135, 5.324)	0.018	1.729 (0.371, 7.519)	0.003
Napsin A
No	Ref	Ref	Ref	Ref
Yes	7.429 (3.494, 15.681)	< 0.001	2.704 (0.489, 15.541)	0.007
CK5/6
No	Ref	Ref	Ref	Ref
Yes	17.667 (6.993, 46.668)	< 0.001	18.668 (2.938, 154.991)	0.042
PAS-D
No	Ref	Ref	Ref	Ref
Yes	3.788 (1.548, 8.676)	0.002	3.521 (0.605, 19.102)	0.067
CK7
No	Ref	Ref	Ref	Ref
Yes	2.100 (1.030, 4.171)	0.036	0.146 (0.021, 0.935)	0.123
PAS
No	Ref	Ref	Ref	Ref
Yes	11.883 (5.542, 25.739)	< 0.001	1.673 (0.307, 7.799)	0.148
Pleural adhesions
No	Ref	Ref	Ref	Ref
Yes	2.940 (1.332, 7.436)	0.013	3.516 (0.800, 19.883)	0.21
D2-40
No	Ref	Ref	Ref	Ref
Yes	5.742 (2.015, 15.355)	0.001	4.325 (0.285, 89.145)	0.252
TTF-1
No	Ref	Ref	Ref	Ref
Yes	2.950 (1.500, 5.827)	0.002	3.817 (0.668, 21.137)	0.253
CD31
No	Ref	Ref	Ref	Ref
Yes	3.288 (1.013, 9.196)	0.031	0.393 (0.013, 10.772)	0.3
Solid
No	Ref	Ref	Ref	Ref
Yes	5.770 (2.159, 14.602)	< 0.001	1.925 (0.246, 13.577)	0.47
Micropapillary
No	Ref	Ref	Ref	Ref
Yes	2.831 (1.355, 5.735)	0.004	2.189 (0.495, 9.065)	0.515
Stretch fiber
No	Ref	Ref	Ref	Ref
Yes	2.440 (1.231, 4.801)	0.01	2.134 (0.578, 7.992)	0.528
EMA, n (%)
No	Ref	Ref	Ref	Ref
Yes	8.723 (2.889, 25.881)	< 0.001	2.237 (0.213, 22.148)	0.588
P63
No	Ref	Ref	Ref	Ref
Yes	10.212 (4.487, 23.219)	< 0.001	9.324 (1.994, 52.880)	0.608
Lobulation
No	Ref	Ref	Ref	Ref
Yes	2.292 (1.146, 4.838)	0.023	2.316 (0.647, 9.247)	0.989
Maximum Diameter	5.159 (1.965, 14.589)	0.001	3.651 (0.759, 20.700)	0.119
FEV1% predicted	0.982 (0.964, 1.000)	0.045	0.979 (0.946, 1.013)	0.12
PLR	1.010 (1.004, 1.016)	0.001	0.994 (0.954, 1.029)	0.067
Lymphocyte	0.475 (0.235, 0.896)	0.03	0.087 (0.001, 2.061)	0.199
BMI	1.172 (1.067, 1.288)	0.001	1.367 (1.161, 1.642)	0.21
CTR	5.724 (2.351, 15.258)	< 0.001	0.988 (0.171, 5.685)	0.284
PNI	0.925 (0.876, 0.977)	0.005	NA (NA, NA)	0.352
Ki-67 positive rate	1.029 (1.010, 1.046)	0.001	0.990 (0.949, 1.028)	0.495
Complement C1q	1.018 (1.007, 1.029)	0.001	1.020 (0.999, 1.042)	0.553
Platelet	1.006 (1.001, 1.011)	0.016	1.012 (0.989, 1.041)	0.747
Albumin	0.942 (0.888, 1.003)	0.047	1.010 (0.896, 1.176)	0.886
Acinar
No	Ref	Ref
Yes	0.827 (0.388, 1.926)	0.639
ASA
1	Ref	Ref
2	1.653 (0.467, 10.515)	0.505
3	3.818 (0.561, 32.139)	0.171
Blood type
A	Ref	Ref
B	0.740 (0.315, 1.736)	0.484
AB	1.152 (0.346, 3.360)	0.804
O	1.088 (0.436, 2.662)	0.853
Bronchus sign
No	Ref	Ref
Yes	1.579 (0.788, 3.099)	0.188
Calcification
No	Ref	Ref
Yes	0.000 (NA, NA)	0.989
Cavitation sign
No	Ref	Ref
Yes	1.040 (0.429, 2.270)	0.925
COPD
No	Ref	Ref
Yes	0.000 (NA, NA)	0.987
CyclinD1
No	Ref	Ref
Yes	3.000 (0.805, 9.151)	0.069
Diabetes
No	Ref	Ref
Yes	0.581 (0.136, 1.708)	0.384
Gender
Female	Ref	Ref
Male	0.660 (0.328, 1.292)	0.232
Hypertension
No	Ref	Ref
Yes	0.671 (0.301, 1.384)	0.3
Lepidic
No	Ref	Ref
Yes	0.514 (0.262, 1.015)	0.052
Location
Centrality	Ref	Ref
Peripherality	1.220 (0.456, 4.238)	0.72
Lymph node enlargement sign
No	Ref	Ref
Yes	1.566 (0.693, 3.295)	0.255
MUC-AC
No	Ref	Ref
Yes	0.348 (0.019, 1.726)	0.308
Papillary
No	Ref	Ref
Yes	1.403 (0.713, 2.737)	0.32
Pleural effusion sign
No	Ref	Ref
Yes	0.000 (NA, NA)	0.985
Shape
Regularity	Ref	Ref
Irregularity	1.273 (0.626, 2.758)	0.52
Smoking history
Non-smoker	Ref	Ref
Smoker	0.918 (0.423, 1.870)	0.82
Spiculation
No	Ref	Ref
Yes	1.885 (0.876, 4.528)	0.126
Vascular penetration sign
No	Ref	Ref
Yes	1.449 (0.671, 3.492)	0.372
Cyfra21-1	0.934 (0.623, 1.078)	0.684
AISI	1.000 (0.999, 1.001)	0.495
Basophil	0.501 (0.000, 48.590)	0.856
Blood Sugar	0.802 (0.556, 1.072)	0.187
CEA	0.939 (0.717, 1.151)	0.602
dNLR	1.062 (0.636, 1.543)	0.778
Eosinophil	1.375 (0.221, 4.520)	0.618
Erythrocyte	0.920 (0.431, 1.956)	0.829
Hemoglobin	0.981 (0.959, 1.002)	0.078
LDH	1.006 (0.998, 1.015)	0.122
MLR	1.803 (0.830, 3.913)	0.096
Monocyte	1.168 (0.731, 1.673)	0.366
MVV% predicted	0.987 (0.971, 1.001)	0.097
Neutrophil	0.945 (0.704, 1.185)	0.668
NLPR	0.000 (NA, NA)	0.597
NLR	1.023 (0.775, 1.215)	0.825
NSE	1.029 (0.988, 1.067)	0.133
Pro_GRP	1.005 (0.979, 1.028)	0.695
SCC	0.960 (0.562, 1.451)	0.867
SII	1.000 (1.000, 1.001)	0.265
SIRI	1.023 (0.799, 1.170)	0.781
5'-NT	0.995 (0.747, 1.271)	0.973

LNM lymph node metastasis, COPD chronic obstructive pulmonary diseases, ASA American Society of Anesthesiologists, PNI prognostic nutritional index, NLR neutrophil–lymphocyte ratio, PLR platelet-lymphocyte ratio, MLR monocyte-lymphocyte ratio, dNLR derived neutrophil-to-lymphocyte ratio, NLPR neutrophil to lymphocyte and platelet ratio, SIRI systemic inflammatory response syndrome, AISI aggregate index of systemic inflammation, SII systemic inflammation index, PIV pan-immune-inflammation value, LDH lactate dehydrogenase, SA serum amyloid, 5'-NT 5'-nucleotidase, Pro-GRP pro-gastrin-releasing peptide, SCC squamous cell carcinoma, Cyfra21-1 cytokeratin 19-fragments, CEA carcinoembryonic antigen, CA125 carcinoma antigen 125, NSE neuron-specific enolase, BMI body mass index, FEV1 forced expiratory volume in one second, MVV maximal voluntary ventilation, CTR consolidation-to-tumor ratio, TTF thyroid transcription factor 1, PAS Periodic Acid-Schiff reaction, PAS-D Periodic Acid-Schiff reaction with diastase, CK 5/6 Cytokeratin 5/6, CK 7 Cytokeratin 7, MUC-AC mucin-AC

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