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Fig. 3 | BMC Cancer

Fig. 3

From: Downregulation of PTPRT elevates the expression of survivin and promotes the proliferation, migration, and invasion of lung adenocarcinoma

Fig. 3

In vitro validation of the influence of PTPRT with cell proliferation in LUAD cell lines. A qRT-PCR of PTPRT in four LUAD cell lines and a human bronchial epithelial cell lines BEAS-2B. B Knockdown of PTPRT (si-PTPRT-921) in A549 cells. C Overexpress of PTPRT (OE-PTPRT) in H1975 cells compared with negative control (OE-NC). D Cell proliferation curves after 4 different treatments (si-NC, si-PTPRT, OE-NC, and OE-PTPRT). Data were shown as the mean ± SD (n = 3). * P < 0.05, ** P < 0.01, *** P < 0.001 by unpaired Student’s t test. E–G The changes of colony formation efficiency upon PTPRT knockdown in non-malignant lung epithelial cells (E, BEAS-2B) and lung cancer cells (F, A549; G, H838). H-I The changes of cell cycle-related genes upon PTPRT knockdown (H) and overexpression (I)

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BMC Cancer

ISSN: 1471-2407

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