Table 4 Univariate analysis and Cox regression analysis of PFS and OS of all patients
Characteristics | PFS mPFS (95%CI) | p value | Cox regression | OS mOS (95%CI) | p value | Cox regression | ||
|---|---|---|---|---|---|---|---|---|
HR(95%CI) | p value | HR(95%CI) | p value | |||||
Sex | Â | 0.187 | Â | Â | Â | Â | Â | Â |
 Male | 7.8 (7.201–8.399) |  |  |  |  |  |  |  |
 Female | 13.9 (2.384–25.416) |  |  |  |  |  |  |  |
Age | Â | 0.455 | Â | Â | Â | 0.066 | Â | Â |
 ≤ 65 | 8.0 (7.465–8.535) |  |  |  | 27.1 (24.519–29.681) |  |  |  |
 > 65 | 7.7 (5.440–9.960) |  |  |  | 16.5 (12.471–20.529) |  |  |  |
Liver metastases |  | 0.000 | 1.862 (1.173–2.957) | 0.008 |  | 0.000 | 1.547 (0.891–2.684) | 0.121 |
 No | 8.3 (7.728–8.872) |  |  |  | 27.1 (22.398–31.802) |  |  |  |
 Yes | 4.7 (3.997–5.403) |  |  |  | 10.9 (8.966–12.834) |  |  |  |
Brain metastases | Â | 0.903 | Â | Â | Â | 0.495 | Â | Â |
 No | 7.8 (7.182–8.418) |  |  |  | 23.2 (15.251–31.149) |  |  |  |
 Yes | 8.0 (7.388–8.612) |  |  |  | 28.2 (17.998–38.402) |  |  |  |
Bone metastases |  | 0.013 | 0.895 (0.570–1.404) | 0.628 |  | 0.000 | 1.563 (0.939–2.603) | 0.086 |
 No | 8.4 (7.293–9.507) |  |  |  | 29.1 (24.633–33.567) |  |  |  |
 Yes | 5.3 (3.887–6.713) |  |  |  | 11.1 (8.102–14.098) |  |  |  |
Smoking history | Â | 0.156 | Â | Â | Â | 0.319 | Â | Â |
 No | 8.4 (6.413–10.387) |  |  |  | 26.9 (18.831–34.969) |  |  |  |
 Yes | 7.8 (6.938–8.662) |  |  |  | 23.2 (13.258–33.142) |  |  |  |
ECOG PS |  | 0.015 | 1.670 (0.943–2.958) | 0.079 |  | 0.028 | 1.563 (0.813–3.004) | 0.180 |
 ≤ 1 | 8.2 (7.670–8.730) |  |  |  | 26.9 (21.758–32.042) |  |  |  |
 > 1 | 5.8 (4.150–7.450) |  |  |  | 10.8 (0.000-24.847) |  |  |  |
Chemotherapy regimen | Â | 0.505 | Â | Â | Â | 0.861 | Â | Â |
 EP | 8.2 (7.301–9.099) |  |  |  | 22.8 (12.910–32.690) |  |  |  |
 EC | 7.8 (7.024–8.576) |  |  |  | 25.6 (14.358–36.842) |  |  |  |
 EL | 8.2 (6.049–10.351) |  |  |  | 27 (18.310–35.690) |  |  |  |
Locoregional thoracic radiotherapy |  | 0.000 | 0.422 (0.28–0.635) | 0.000 |  | 0.000 | 0.540 (0.333–0.878) | 0.013 |
 No | 6.0 (4.857–7.143) |  |  |  | 14.6 (10.51–18.690) |  |  |  |
 Yes | 12.3 (9.364–15.236) |  |  |  | 32.1 (25.602–38.598) |  |  |  |
LDH |  | 0.021 | 1.163 (0.790–1.711) | 0.444 |  | 0.002 | 1.580 (1.006–2.482) | 0.047 |
 ≤ 250 | 8.3 (7.505–9.095) |  |  |  | 27.0 (23.664–30.336) |  |  |  |
 >250 | 7.4 (6.161–8.639) |  |  |  | 14.8 (12.409–17.191) |  |  |  |