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Table 2 Comparison of efficacy between PD-1 group and PD-L1 group

From: Efficacy and safety of anti-PD-1 inhibitor versus anti-PD-L1 inhibitor in first-line treatment of extensive-stage small cell lung cancer: a multicenter retrospective study

 

PD-1 group

PD-L1 group

p value

CR

1

0

 

PR

53

68

 

SD

9

13

 

PD

5

5

 

ORR (%)(CR + PR)

54 (79.4)

68 (79.1)

0.959

DCR (%) (CR + PR + SD)

63 (92.6)

81 (94.2)

0.956

PFS

   

 Events, n (%)

56 (82.4)

65 (75.6)

 

 Median, months (95%CI)

7.6 (6.936–8.264)

8.3 (7.717–8.883)

0.415

 6-month rate (95%CI)

64.7% (53.1–76.3)

67.4% (57.4–77.4)

0.853

 12-month rate (95%CI)

26.6% (15.4–37.8)

34.9% (24.3–45.5)

0.345

 18-month rate (95%CI)

16.6% (7.2–26.0)

23.7% (13.7–33.7)

0.376

 24-month rate (95%CI)

12.1% (3.5–20.7)

10.4% (0.0-20.8)

0.997

OS

   

 Events, n (%)

40 (58.8)

46 (53.5)

 

 Median, months (95%CI)

26.9 (13.805–39.995)

25.6 (16.214–34.986)

0.859

 6-month rate (95%CI)

92.6% (86.3–98.9)

95.3% (90.8–99.8)

0.716

 12-month rate (95%CI)

69.0% (58.0–80.0)

80.1% (71.7–88.5)

0.161

 18-month rate (95%CI)

54.9% (42.9–66.9)

56.2% (45.4–67.0)

0.992

 24-month rate (95%CI)

50.5% (38.0–63.0)

50.7% (39.1–62.3)

0.985

  1. ORR: objective response rate, DCR: disease control rate, PFS: progression free survival, OS: overall survival