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Table 3 Follow-up workflow

From: Adjuvant medial versus entire supraclavicular lymph node irradiation in high-risk early breast cancer (SUCLANODE): a protocol for a multicenter, randomized, open-label, phase 3 trial

 

Baseline

During RT

End of RT

First 2 years after RT

3 ~ 5 years after RT

Beyond 5 years after RT

  

Every

1 ~ 2 week

 

Every 3 months

Every 6 months

Every 12 months

Clinical examination

X

X

X

X

X

X

Hematology tests

X

X

X

X

X

X

Blood chemistry/tumor-markers tests

X

  

X

X

X

Ultrasounds

X

  

X

X

X

Mammogram

X

  

every 12 months after RT

Chest CT*

X

  

every 12 months after RT

Acute radiation adverse events

X

X

X

At 2 weeks and 3 month after RT

  

Late radiation adverse events

X

  

At 3 month after RT, and than every 12 months

PROs/QoL questionnaires

X

  

At 3 month after RT, and than every 12 months

Blood biomarker samples

X

 

Carried out if possible

  1. * Additional imaging such as positron emission tomography /computed tomography (PET/CT), bone emission computed tomography (ECT), brain (MRI), or biopsy will be performed as indicated for suspected recurrence or metastasis
  2. Abbreviations: RT = radiation therapy; CT = computer tomography; MRI = magnetic resonance imaging; PROs = patient reported outcomes; QoL = quality of life