Fig. 2

PA upregulated CCL2 in BMA and promoted the proliferation, migration, and invasion abilities of PCa cells. PA was used for stimulating the adipocytic differentiation of MSCs for 48 h. A The mRNA expression levels of CCL2/KLF7/GPR40/GPR120 in BMA were determined using qRT-PCR. B The protein expression levels of CCL2/KLF7/GPR40/GPR120 in BMA were determined using Western Blot. C The CCL2 secretion levels were determined using ELISA. D The oil red O staining was performed. E The mRNA expression levels of HSL/ATGL in BMA were determined using qRT-PCR. F The conditioned medium obtained from the BMA incubated with PA (CM-BMA-PA) was adopted for culturing the PCa cell lines. The (G, H) proliferation, (I, J) invasion, and (K, L) migration abilities of PC-3 cells and 22RV1 cells were determined. In the t-test, the differences with *P < 0.05, **P < 0.01, and ***P < 0.001 were statistically significant