Fig. 3
(a) Volcano plots [-log10(P-value) vs. log2(fold change)] for each comparison of wild-type and resistant HCC1395 (left), MDA-MB-231 (middle), and MDA-MB-468 (right) cells after long-term ACT treatment. The significant downregulated (green) and upregulated (red) transcripts are shown in each volcano plot. (b) A list of the 50 most significant genes in each upregulated DEG following long-term ACT treatment. The function of genes was annotated based on the GeneRIF database. (c) Heat map showing the relative abundance of selected drug resistance-related genes. The predicted locations of proteins encoded by drug resistance-related genes were categorized based on the Human Protein Atlas