Table 1 Univariate and multivariate analysis of 3-DFS in stage II dMMR patients
Variables | N (%) | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | ||
Age (years) | |||||
≥ 65 | 53(20.2) | 1.16(0.43–3.15) | 0.769 | ||
< 65 | 209(79.8) | ||||
Gender | |||||
Male | 162(61.8) | 1.35(0.55–3.32) | 0.508 | ||
Female | 100(38.2) | ||||
Family history | |||||
Yes | 110(42.0) | 1.14(0.49–2.64) | 0.762 | ||
No | 152(58.0) | ||||
pT4 category | |||||
Yes | 46(17.6) | 2.93(1.23–6.98) | 0.015 | 2.58(1.06–6.25) | 0.037 |
No | 216(82.4) | ||||
Lymphatic node number | |||||
< 12 LNs | 41(15.7) | 2.16(0.85–5.53) | 0.107 | ||
≥ 12 LNs | 221(84.3) | ||||
LVI | |||||
Yes | 29(11.1) | 2.54(0.94–6.89) | 0.067 | 1.71(0.60–4.89) | 0.316 |
No | 233(88.9) | ||||
PNI | |||||
Yes | 21(8.0) | 1.18(0.28–5.04) | 0.830 | ||
No | 241(92.0) | ||||
Histological grade | |||||
Poorly differentiated | 98(37.4) | 2.08(0.90–4.82) | 0.087 | 1.65(0.68–4.02) | 0.270 |
Moderately differentiated | 164(62.6) | ||||
Pre-CEA | |||||
Abnormal (> 5 ng/ml) | 77(29.4) | 3.08(1.33–7.12) | 0.009 | 2.93(1.26–6.82) | 0.013 |
Normal | 185(80.6) | ||||
High-risk Factor | |||||
Yes | 179(68.3) | 3.08(0.91–10.41) | 0.056 | ||
No | 83(31.7) | ||||
Multiple risk Factor | |||||
Yes | 91(34.7) | 2.88(1.23–6.74) | 0.015 | ||
No | 171(65.3) | ||||