Table 2 Univariate and multivariate analysis of prognostic factors for OS in newly diagnosed patients with DLBCL

Sex (male vs. female)

1.26

0.91–1.75

0.165

Age (>60 vs. ≤60)

1.49

1.09–2.04

0.014

1.25

0.88–1.76

0.215

Ann Arbor Stage (III–IV vs. I–II)

2.65

1.78–3.95

<0.001

1.39

0.87–2.23

0.166

Extranodal disease (>1 vs ≤1)

1.87

1.36–2.56

<0.001

1.09

0.76–1.55

0.645

ECOG score (2–4 vs. 0–1)

3.01

2.19–4.15

<0.001

1.83

1.24–2.70

0.002

LDH (>ULN vs. normal)

3.13

2.21–4.42

<0.001

1.93

1.29–2.88

0.001

B symptoms (present vs. absent)

2.27

1.65–3.13

<0.001

1.28

0.89–1.85

0.180

Serum ApoA1 (high vs. low)

0.39

0.28–0.53

<0.001

0.66

0.46–0.94

0.022

Subtype (non-GCB vs. GCB)

1.76

1.21–2.57

0.003

1.38

1.04–1.83

0.024

Regimen (CHOP-like vs. R-CHOP-like)

2.00

1.38–2.90

<0.001

2.21

1.51–3.23

<0.001