Table 4 Median lymphocyte subset levels in different BC subtypes
From: Immune characteristics and clinical significance of peripheral blood lymphocytes in breast cancer
Lymphocyte subsets | Reference (%) | Baseline | ||
ALL | Adjuvant therapy | Neoadjuvant therapy | ||
CD3 + T | 67.00–76.00 | 67.50(61.00,73.50) | 68.00(61.00,74.00) | 61.00*(55.00,71.00) |
CD8 + T | 21.00–32.00 | 29.00(25.25,35.00) | 29.00(25.00,35.00) | 30.00(27.00,35.00) |
CD4 + T | 35.00–46.00 | 39.00(36.00,45.00) | 41.00(36.00,45.00) | 38.00(35.00,39.00) |
CD4+/CD8 + T | 1.09–2.17 | 1.33(1.04,1.78) | 1.32(1.05,1.79) | 1.33(1.01,1.48) |
Treg | 7.48–15.09 | 5.82*(3.93,7.58) | 5.51*(3.88,7.38) | 5.85*(4.72,9.29) |
PD-L1 + T | 92.35–98.18 | 88.41*(82.22,94.58) | 87.21*(81.60,93.77) | 94.14(88.64,96.61) |
PD-1 + T | 15.96–26.32 | 21.81(19.31,29.13) | 21.17(19.00,28.90) | 24.14(21.76,29.96) |
LAG-3 + T | 1.21–3.03 | 2.24(1.77,2.67) | 2.30(1.78,2.67) | 1.92(1.57,2.67) |
TIM3 + T | 0.90–2.06 | 1.05(0.67,1.91) | 1.07(0.66,1.91) | 0.96(0.75,1.81) |
CTLA-4 + T | 11.06–28.84 | 11.95(7.82,17.71) | 12.46(8.28,17.77) | 8.50*(5.62,16.56) |
CD19 + CD32 + B | 10.36–16.87 | 12.64(9.59,15.00) | 12.88(9.53,14.81) | 12.32(10.43,15.74) |
NK | 11.00–23.00 | 18.51(14.35,23.66) | 18.13(13.47,23.83) | 18.70(14.91,22.55) |
Lymphocyte subsets | Reference (%) | Baseline | ||
HR + HER2- | HER2+ | TNBC | ||
CD3 + T | 67.00–76.00 | 69.00(59.00,72.00) | 65.00*(61.00,71.75) | 68.00(62.00,76.00) |
CD8 + T | 21.00–32.00 | 31.00(27.00,36.00) | 28.00(24.25,30.00) | 28.00(27.00,38.00) |
CD4 + T | 35.00–46.00 | 38.00(35.00,45.00) | 41.50(37.25,44.75) | 41.00(36.00,43.00) |
CD4+/CD8 + T | 1.09–2.17 | 1.25(0.96,1.64) | 1.52(1.22,1.84) | 1.48(0.93,1.67) |
Treg | 7.48–15.09 | 4.97*(3.96,6.49) | 5.15*(3.52,7.57) | 6.38*(5.84,7.99) |
PD-L1 + T | 92.35–98.18 | 88.64*(85.04,93.63) | 86.73*(81.38,93.74) | 93.42(88.04,96.96) |
PD-1 + T | 15.96–26.32 | 21.04(19.31,26.89) | 24.01(21.13,29.49) | 22.49(19.00,29.87) |
LAG-3 + T | 1.21–3.03 | 2.10(1.77,2.76) | 2.08(1.79,2.50) | 2.40(1.73,3.23) |
TIM3 + T | 0.90–2.06 | 1.08(0.75,1.88) | 1.08(0.65,1.92) | 0.75*(0.54,1.83) |
CTLA-4 + T | 11.06–28.84 | 12.46(8.25,17.28) | 11.95(7.72,18.07) | 11.77(7.77,16.55) |
CD19 + CD32 + B | 10.36–16.87 | 12.32(10.05,13.81) | 13.55(9.21,16.33) | 12.41(8.80,15.21) |
NK | 11.00–23.00 | 18.40(14.38,24.14) | 18.01(15.24,21.73) | 18.70(10.28,22.36) |