FERMT1 promotes cell migration and invasion in non-small cell lung cancer via regulating PKP3-mediated activation of p38 MAPK signaling

Liu, Bao; Feng, Yan; Xie, Naiying; Yang, Yang; Yang, Dameng

doi:10.1186/s12885-023-11812-3

Fig. 6

From: FERMT1 promotes cell migration and invasion in non-small cell lung cancer via regulating PKP3-mediated activation of p38 MAPK signaling

PKP3 knockdown attenuated FERMT1-induced promotive effects on NSCLC cells. (A and B) Cell motilities following transfection with the indicated plasmids in NSCLC cells were observed in migration and invasion assays. (C) After co-transfection with the specified plasmids, Western blotting was employed to detect the protein levels. (D– K) Quantification of the protein levels of FERMT1 (D), PKP3 (E), E-cadherin (F), N-cadherin (G), Vimentin (H), p38 (I), p-p38 (J) and p-p38/p38 (K) in (C). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Fig. 6

BMC Cancer

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