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Table 3 Results of univariate and multivariate analyses of grade ≥ 2 RP in the whole cohort

From: Novel model integrating computed tomography-based image markers with genetic markers for discriminating radiation pneumonitis in patients with unresectable stage III non-small cell lung cancer receiving radiotherapy: a retrospective multi-center radiogenomics study

Variables

Univariate analysis

Multivariate analysis

OR (95% CI)

p

OR (95% CI)

p

Gender

Male

1

   
 

Female

0.404 (0.084–1.949)

0.259

  

Age

≤ 60

1

   
 

>60

1.069 (0.449–2.546)

0.881

  

Smoking status

Never

1

   
 

Former/current

1.067 (0.391–2.915)

0.899

  

Tumor location

Left Lung

1

0.969

  
 

Right Lung

1.088 (0.448–2.638)

0.852

  
 

Others

1.292 (0.107–15.598)

0.840

  

Histology

ADC

1

   
 

SCC

2.496 (0.903-6.900)

0.078

3.607 (1.006–12.937)

0.049

Clinical stage

IIIA

1

0.280

  
 

IIIB

1.318 (0.513–3.387)

0.567

  
 

IIIC

3.200 (0.767–13.353)

0.111

  

Radiation dose

≥60 Gy

1

   
 

< 60 Gy

0.645 (0.237–1.757)

0.391

  

Chemoradiotherapy

SCRT

1

   
 

CCRT

0.683 (0.287–1.626)

0.389

  

Radiation therapy

IMRT

1

   
 

3D-CRT

1.680 (0.636–4.438)

0.295

  

XRCC1 (rs25487)

Wild

1

   
 

Mutation

3.218 (1.285–8.060)

0.013

5.698 (1.749–18.561)

0.004

XRCC5 (rs3835)

Wild

1

   
 

Mutation

0.567 (1.148–2.181)

0.409

  

MTHFR (rs1801133)

Wild

1

   
 

Mutation

2.451 (0.757–7.939)

0.135

  

NQO1 (rs1800566)

Wild

1

   
 

Mutation

2.609 (0.886–7.679)

0.082

3.140 (0.842–11.716)

0.089

ZNF217

Wild

1

   
 

Amplification

2.556 (0.342–19.070)

0.360

  

POLD1

Wild

1

   
 

Mutation

3.627 (0.758–17.355)

0.107

  

Rad-score

Low

1

   
 

High

8.014 (2.962–21.685)

< 0.001

12.216 (3.693–40.410)

< 0.001

  1. Abbreviations: ADC: adenocarcinoma, SCC: squamous cell carcinoma, SCRT: sequential chemoradiotherapy, CCRT: concurrent chemoradiotherapy, IMRT: intensity modulated radiation therapy, 3D-CRT: 3-dimensional conformal radiation therapy, CNV: copy number variation, OR: odds ratio, CI: confidence interval
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BMC Cancer

ISSN: 1471-2407

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