Table 1 Demographic and clinicopathologic features of the study cohort
Variables | Overall, (n = 318) | Recurrence, (n = 28) | No recurrence, (n = 290) | p value |
|---|---|---|---|---|
Age, years | ||||
Mean (SD) | 36.97 (10.39) | 36.10 (8.89) | 37.05 (10.53) | 0.643 |
Min, max | 16, 86 | 21, 56 | 16, 86 | |
Age categories, n (%) | ||||
≤ 36 years | 142 (44.7) | 14 (50) | 128 (44.1) | 0.558 |
> 36 years | 176 (55.3) | 14 (50) | 162 (55.9) | |
BMI | ||||
Mean (SD) | 25.41 (4.70) | 25.15 (5.23) | 25.44 (4.65) | 0.815 |
Min, max | 15.06, 39.03 | 15.2, 37.46 | 15.06, 39.03 | |
BMI categories, n (%) | ||||
Non-obesity | 265 (83.3) | 24 (85.7) | 241 (83.1) | 0.723 |
obesity | 53 (16.7) | 4 (14.3) | 49 (16.9) | |
Breast feeding, n (%) | 196 (61.6) | 15 (53.6) | 181 (62.4) | 0.417 |
Oral contraceptive use, n (%) | 70 (22) | 12 (42.9) | 58 (20) | 0.008 |
Smoking, n (%) | 17 (5.3) | 5 (17.9) | 12 (4.1) | 0.002 |
Family history of breast cancer, n (%) | 45 (14.2) | 5 (17.9) | 40 (13.8) | 0.556 |
Side n (%) | ||||
Left | 148 (47.7) | 9 (34.6) | 139 (48.9) | 0.162 |
Right | 162 (52.3) | 17 (65.4) | 145 (51.1) | |
Margins, n (%) | ||||
Circumscribed | 227 (71.4) | 21 (75) | 206 (71) | 0.627 |
Micro lobulated | 9 (2.8) | 0 (0) | 9 (3.1) | |
Indistinct | 82 (25.8) | 7 (25) | 75 (25.9) | |
Echo pattern, n (%) | ||||
Hypoechoic | 308 (96.9) | 24 (85.7) | 284 (97.9) | < 0.001 |
Isoechoic | 4 (1.3) | 0 (0) | 4 (1.4) | |
Hyperechoic | 6 (1.9) | 4 (14.3) | 2 (0.7) | |
Surgical treatment n (%) | ||||
Initial surgery | ||||
Local excision | 264 (83) | 24 (85.7) | 240 (82.8) | 0.734 |
Wide excision | 48 (15.1) | 4 (14.3) | 44 (15.2) | |
Mastectomy | 6 (1.9) | 0 | 6 (2.1) | |
Re-excision after local excision | ||||
Yes | 104 (39.4) | 8 (33.3) | 96 (40) | 0.730 |
No | 160 (60.6) | 16 (66.7) | 144 (60) | |
Surgical margin n (%) | ||||
Negative | 168 (52.8) | 12 (42.9) | 156 (53.8) | 0.268 |
Positive | 150 (47.2) | 16 (57.1) | 134 (46.2) | |
Size, cm | ||||
Mean (SD) | 4.57 (2.6) | 6.09 (3.18) | 4.42 (2.5) | 0.004 |
Min, max | 1,19 | 2, 13 | 1,19 | |
Size categories, n (%) | ||||
≤ 4 cm | 197 (61.9) | 8 (28.6) | 189 (65.2) | < 0.001 |
> 4 cm | 121 (38.1) | 20 (71.4) | 101 (34.8) | |
Histologic subtype n (%) | ||||
benign | 267 (83.9) | 20 (71.4) | 247 (85.1) | 0.037 |
borderline | 24 (7.6) | 2 (7.1) | 22 (7.6) | |
malignant | 27 (8.5) | 6 (21.4) | 21 (7.3) | |
Mitotic Rate | ||||
Mean (SD) | 2.27 (3.74) | 3.86 (4.03) | 2.11 (3.68) | 0.001 |
Min, max | 0,30 | 0,13 | 0,30 | |
Mitotic Rate categories, n (%) | ||||
≤ 2 | 241 (75.8) | 14 (50) | 227 (78.3) | 0.001 |
> 2 | 77 (24.2) | 14 (50) | 63 (21.7) | |
Heterogeneous stroma n (%) | ||||
Absent | 193 (60.7) | 12 (42.9) | 181 (62.4) | 0.043 |
Present | 125 (39.3) | 16 (57.1) | 109 (37.6) | |
Stromal overgrowth n (%) | ||||
Absent | 216 (68.1) | 10 (35.7) | 206 (71.3) | < 0.001 |
Present | 101 (31.9) | 18 (64.3) | 83 (28.7) | |
Stromal cell atypia n (%) | ||||
Absent | 139 (44) | 4 (14.3) | 137 (46.9) | 0.001 |
Present | 177 (56) | 24 (85.7) | 153 (53.3) | |