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Fig. 6 | BMC Cancer

Fig. 6

From: Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28

Fig. 6

CAF-derived exosomes and circ_0067557 promoted tumor growth in CRC xenografts. Nude mice were injected with 100 µL normal saline in control group, 100 µL CAF-derived exosomes (10 µg, CAF-exos), 10 mg/kg 5-FU/L-OHP in experimental groups, respectively. (A) Tumor-bearing nude mice and excised tumors were photographed after four weeks. (B) The growth of the tumor was estimated by calculating the volume on days 7, 14, 21, and 28. (C) Tumor weights were measured at the end of four weeks. (D) Pathological changes in tumors were assessed by H&E staining. (E) Apoptosis was determined by TUNEL staining. (F) Lin28A and Lin28B expression was analyzed by IHC; 200× magnification

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BMC Cancer

ISSN: 1471-2407

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