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Fig. 4 | BMC Cancer

Fig. 4

From: Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28

Fig. 4

Circ_0067557 affected malignant phenotypes of HCT116 cells. Circ_0067557 was overexpressed or silenced in HCT116 cells. (A) Circ_0067557, Lin28A, and Lin28B expression levels were determined by RT-qPCR. (B) Lin28A and Lin28B expression levels were detected by Western blotting. (C) Drug resistance was determined by CCK-8 assay at 24, 48, and 72 h. (D) Proliferation was monitored by EdU staining. (E) Sphere-forming assay. (F) Apoptosis was examined by flow cytometry. CD133, CD44, and OCT4 expression levels were detected by Western blotting (G) and RT-qPCR (H). (I) The levels of EMT and cycle-related proteins were assessed by Western blotting

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BMC Cancer

ISSN: 1471-2407

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