Table 2 Quality of evidence assessment
Participants (studies) Follow-up | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | Overall certainty of evidence | Study event rates (%) | Relative effect (95% CI) | Anticipated absolute effects | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
With Treatment of BC | With TCM | Risk with Treatment of BC | Risk difference with TCM | ||||||||
Total score of KMI | |||||||||||
2023 (28 RCTs) | serious a | not serious | not serious | not serious | none | ⨁⨁⨁◯ Moderate | 1010 | 1013 | – | – | S MD 1.84 SD lower (2.21 lower to 1.46 lower) |
Hot flashes and night sweats in KMI | |||||||||||
387 (6 RCTs) | serious a | serious b | not serious | serious c | none | ⨁◯◯◯ Very low | 194 | 193 | – | – | S MD 0.68 SD lower (1.1 lower to 0.27 lower) |
Paresthesia in KMI | |||||||||||
379 (6 RCTs) | serious a | not serious | not serious | serious c | none | ⨁⨁◯◯ Low | 190 | 189 | – | MD 0.48 lower (0.74 lower to 0.21 lower) | |
Osteoarthralgia in KMI | |||||||||||
420 (7 RCTs) | serious a,d | serious b | not serious | not serious | none | ⨁⨁◯◯ Low | 210 | 210 | – | – | S MD 0.41 SD lower (0.6 lower to 0.21 lower) |
Anxiety in KMI | |||||||||||
432 (7 RCTs) | serious a | not serious | not serious | not serious | none | ⨁⨁⨁◯ Moderate | 216 | 216 | – | MD 0.85 lower (1.13 lower to 0.58 lower) | |
Insomnia in KMI | |||||||||||
479 (8 RCTs) | serious a,d | serious b | not serious | not serious | none | ⨁⨁◯◯ Low | 240 | 239 | – | – | S MD 0.61 SD lower (0.8 lower to 0.43 lower) |
ORR | |||||||||||
871 (13 RCTs) | not serious | serious b | not serious | not serious | none | ⨁⨁⨁◯ Moderate | 250/439 (56.9%) | 368/432 (85.2%) | not es timable | 569 per 1000 | |
E2 | |||||||||||
1484 (21 RCTs) | serious a,d | very serious b | not serious | not serious | none | ⨁◯◯◯ Very low | 724 | 760 | – | – | S MD 0.02 SD higher (0.24 lower to 0.28 higher) |
FSH | |||||||||||
1404 (20 RCTs) | serious d | serious b | not serious | not serious | none | ⨁⨁◯◯ Low | 685 | 719 | – | MD 0.09 SD lower (0.84 lower to 0.66 higher) | |
LH | |||||||||||
1081 (15 RCTs) | serious d | serious b | not serious | not serious | none | ⨁⨁◯◯ Low | 525 | 556 | – | MD 0.99 lower (1.38 lower to 0.6 lower) | |
AEs | |||||||||||
1186 (6 RCTs) | not serious | serious b | not serious | not serious | none | ⨁⨁⨁◯ Moderate | 67/598 (11.2%) | 45/588 (7.7%) | not es timable | 112 per 1000 | |