Prognostic significance of multiparametric flow cytometry minimal residual disease at two time points after induction in pediatric acute myeloid leukemia

Table 3 Multivariate analysis by Cox regression of 459 patients with available MFC-MRD data at both TP1 and TP2

Risk factor	Overall survival			Event-free survival
	HR	95% CI	P-value	HR	95% CI	P-value
WBC at diagnosis (≥ 50 × 10⁹/L)	1.202	0.750–1.926	0.445	1.263	0.859–1.858	0.235
RUNX1-RUNX1T1	0.326	0.161–0.660	0.002	0.314	0.178–0.553	0.000
CBFB-MYH11	0.254	0.062–1.046	0.058	0.232	0.073–0.738	0.013
FLT3-ITD mutations	1.535	0.831–2.837	0.171	1.482	0.892–2.462	0.129
MRD ≥ 0.1% before start of consolidation	2.466	1.511–4.027	0.000	2.358	1.553–3.580	0.000

TP2 at the end of the second induction course (before start of consolidation), WBC white blood cell count, FAB French-American-British, MFC multiparametric flow cytometry, MRD minimal residual disease, HR hazard ratio, CI confidence interval

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