Table 2 Univariate analysis by Cox regression of 459 patients with available MFC-MRD data at TP2

Sex (male)

1.098

0.705–1.711

0.679

1.086

0.752–1.569

0.660

WBC at diagnosis (≥ 50 × 10⁹/L)

1.560

0.997–2.441

0.051

1.630

1.131–2.350

0.009

FAB classification (M7)

1.774

0.887–3.549

0.105

1.633

0.899–2.966

0.107

RUNX1-RUNX1T1

0.309

0.155–0.619

0.001

0.306

0.175–0.534

0.000

CBFB-MYH11

0.294

0.072–1.199

0.088

0.291

0.092–0.914

0.035

MLLT3-KMT2A

0.571

0.209–1.561

0.275

0.667

0.311–1.430

0.298

KMT2A rearrangement excluding MLLT3-KMT2A

1.599

0.866–2.955

0.134

1.292

0.752–2.220

0.353

-7 or 7q-

1.895

0.764–4.697

0.168

1.114

0.455–2.728

0.813

FLT3-ITD mutations

1.953

1.078–3.538

0.027

1.969

1.206–3.215

0.007

ASXL1 mutations

0.770

0.282–2.104

0.610

0.908

0.423–1.948

0.804

NPM1 mutations

1.401

0.344–5.705

0.638

0.943

0.233–3.817

0.935

Biallelic mutated CEBPA

0.340

0.047–2.447

0.284

0.680

0.216–2.140

0.510

MRD ≥ 0.1% before consolidation

2.882

1.774–4.683

0.000

2.703

1.787–4.088

0.000