Table 7 Adverse events
Rechallenge (n = 128) | Regorafenib (n = 266) | p | p | |||
|---|---|---|---|---|---|---|
Any Grade | Grade3/4 | Any Grade | Grade3/4 | Any Grade | Grade 3/4 | |
n(%) | ||||||
Hematological | ||||||
Neutropenia | 48 (37.5) | 16 (12.5) | 83 (31.2) | 33 (12.4) | .214 | .979 |
Thrombocytopenia | 37 (28.9) | 5 (3.9) | 87 (32.7) | 10 (3.8) | .447 | .943 |
Anemia | 58 (45.3) | 0 (0) | 148 (55.6) | 9 (3.4) | .055 | .034 |
Non-hematological | ||||||
Nausea | 55 (43) | 3 (2.3) | 174 (65.4) | 26 (9.8) | < .001 | .007 |
Diarrhea | 37 (28.9) | 2 (1.6) | 154 (39.1) | 21 (7.9) | < .001 | .011 |
Mucositis | 28 (21.9) | 0 (0) | 141 (53) | 17 (6.4) | < .001 | .002 |
Acneiform rash | 7 (5.5) | 1 (0.8) | 69 (25.9) | 10 (3.8) | < .001 | .112 |
Hepatotoxicity | 10 (7.8) | 0 (0) | 186 (30.1) | 5 (1.9) | < .001 | .179 |
Renal toxicity | 12 (9.4) | 0 (0) | 30 (11.3) | 2 (0.8) | .566 | > .999 |
Neuropathy | 55 (43) | 8 (6.3) | 57 (21.4) | 4 (1.5) | < .001 | .023 |