Table 6 Progression free and Overall Survival according to Response to Prior Lines of Therapy
Rechallenge (n = 128) | Regorafenib (n = 266) | p | |
|---|---|---|---|
Median PFS | |||
Responded to both lines of prior therapy | 6.57 (4.95–8.20) | 4.3 (3.70–4.9) | .170 |
Responded to one line of prior therapy | 4.37 (1.97–6.77) | 3.94 (2.77–5.12) | .763 |
Resistant to both | 2.96 (2.75–3.16) | ||
Median OS after third-line of treatment | |||
Responded to both lines of prior therapy | 11.99 (9.49–14.49) | 8.08 (6.88–9.29) | < .001 |
Responded to one line of prior therapy | 8.15 (0.01–17.81) | 6.97 (4.62–9.31) | .031 |
Resistant to both | 3.94 (2.83–5.06) | ||