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Fig. 1 | BMC Cancer

Fig. 1

From: SARIFA as a new histopathological biomarker is associated with adverse clinicopathological characteristics, tumor-promoting fatty-acid metabolism, and might predict a metastatic pattern in pT3a prostate cancer

Fig. 1

Definition of Stroma-AReactive-Invasion-Front-Areas (SARIFA) as haematoxylin & eosin (H&E) based histopathologic biomarker. SARIFA positivity is defined by the direct contact between adipocytes and tumor cells without intervening desmoplastic reaction, and SARIFA positivity is not restricted to a certain histology as it occurs in prostate cancer with glandular (A, C) as well as more solid (B, D) growth pattern. A, B Overviews of invasion front in periprostatic soft tissue, scale bar: 200 µm. C, D Close-ups of SARIFA-positive area with tumor cells directly adjacent to adipocytes, scale bar: 50 µm

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BMC Cancer

ISSN: 1471-2407

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