Table 1 Summary of potential targets and pathways of NBAT-1
Cancer type | Expression | Potential target | Pathway | Biological Behaviour | References |
|---|---|---|---|---|---|
Neuroblastoma | Downregulated | SOX9 and NRSF/REST | NBAT-1/NRSF/REST pathway; NBAT-1/EZH2/target genes(SOX9、OSMR、VCAN) pathway | Cell proliferation, invasion and neuronal differentiation | [20] |
Neuroblastoma | Downregulated | MYCN | NBAT-1/CASC15/MYCN/USP36/COL18A1 axis | Cell proliferation | [21] |
Neuroblastoma | Downregulated | CRM1, MDM2 | p53/NBAT-1/CRM1, MDM2 axis | Chemotherapeutic response | [22] |
Glioma | Downregulated | miR‐21 | NBAT-1/miR‐21/SOX7 axis | Cell proliferation, migration and invasion | [23] |
Glioma | Downregulated | Akt | NBAT-1/Akt pathway | Cell proliferation | [24] |
Lung cancer | Downregulated | RAC1 | NBAT-1/RAC1 pathway | Cell proliferation and apoptosis | [25] |
Non-small cell lung cancer | Downregulated | ATG7 | NBAT1/PSMD10/ATG7pathway | Autophagy | [26] |
Osteosarcoma | Downregulated | miR-21 | NBAT-1/miR-21/PTEN, PDCD4, TPM1 and RECK axis | Cell proliferation, migration and invasion | [27] |
Gastric cancer | Downregulated | Sox9 | NBAT-1/Sox9 feedback regulation | Cell proliferation, apoptosis, angiogenesis, migration and invasion | [28] |
Gastric cancer | Downregulated | PTEN | NBAT-1/PTEN axis | Cell proliferation and apoptosis | [29] |
Breast cancer | Downregulated | Dkk1 | NBAT-1/EZH2/DKK1 pathway | Migration and invasion | [30] |
Epithelial ovarian cancer | Downregulated | ERK1/2 and AKT | NBAT-1/ERK1/2 and AKT signalling pathways | Cell proliferation, migration and invasion | [31] |
Hepatocellular carcinoma | Downregulated | c-Myc | NBAT-1/IGF2BP1 and c-Myc | Cell proliferation and apoptosis | [32] |
Bladder cancer | Downregulated | EMT | NBAT-1/EMT pathway | Cell proliferation, migration and apoptosis | [33] |
Colorectal Carcinoma | Downregulated | miR-4504 | NBAT-1/miR-4504/WWC3/LATS1/YAP axis | Chemoresistance of CRC | [34] |
Endometrial Cancer | Downregulated | miR-21-5p | NBAT-1/miR-21-5p/PTEN axis | Cell Metastasis, apoptosis and invasion | [35] |
Renal carcinoma | Downregulated | miR-346 | NBAT1/miR-346/GSK-3β axis | cell proliferation, migration, and invasion | [36] |