Table 3 Univariate and multivariate cox regression analysis of factors associated with OS and DFS

APOBEC2(A) and CD66b(B)

A⁺ and B high

Ref

A- and B low

1.867 (1.255,2.776)

0.002

1.267 (0.807,1.990)

0.304

1.869 (1.256,2.779)

0.002

1.248 (0.795,1.961)

0.336

A- and B high

1.596 (0.996,2.556)

0.052

1.436 (0.865,2.383)

0.162

1.622 (1.013,2.598)

0.044

1.497 (0.904,2.479)

0.117

A⁺ and B low

1.348 (0.923,1.970)

0.122

0.924 (0.607,1.409)

0.715

1.360 (0.931,1.987)

0.112

1.183 (0.807,1.733)

0.389

Age (median,58 years)

> 58

1.277 (0.952,1.715)

0.103

1.278 (0.952,1.715)

0.103

≤ 58

Gender

Female

1.233 (0.899,1.692)

0.194

1.221 (0.890,1.676)

0.215

Male

Size(median,4.0 cm)

> 4.0

3.217 (2.386,4.335)

< 0.001

1.877 (1.358,2.594)

< 0.001

3.232 (2.398,4.357)

< 0.001

1.898 (1.374,2.622)

< 0.001

≤ 4.0

Differentiation grade

Poor

1.754 (1.294,2.377)

< 0.001

1.407 (0.954,2.075)

0.085

1.747 (1.290,2.368)

< 0.001

1.424 (0.966,2.099)

0.074

Well + moderate

Lauren’s histologic type

Diffuse

1.327 (0.983,1.792)

0.065

0.924 (0.607,1.409)

0.715

1.316 (0.975,1.777)

0.073

0.904 (0.595,1.373)

0.634

Intestinal

TNM stage

III + VI

4.867 (3.537,6.699)

< 0.001

3.206 (2.244,4.581)

< 0.001

4.870 (3.539,6.702)

< 0.001

3.207 (2.246,4.578)

< 0.001

I + II

Chemotherapy

No

0.336 (0.225,0.503)

< 0.001

0.648 (0.421,0.996)

0.048

0.335 (0.224,0.502)

< 0.001

0.642 (0.418,0.986)

0.043

Yes