Table 2 Univariate and multivariate cox regression analysis of factors associated with OS and DFS

APOBEC2

Positive

0.656 (0.486,0.884)

0.006

0.816 (0.574,1.161)

0.259

0.653 (0.485,0.881)

0.005

0.821 (0.578,1.166)

0.270

Negative

Age (median,58 years)

> 58

1.277 (0.952,1.715)

0.103

1.278 (0.952,1.715)

0.103

≤ 58

Gender

Female

1.233 (0.899,1.692)

0.194

1.221 (0.890,1.676)

0.215

Male

Size(median,4.0 cm)

> 4.0

3.217 (2.386,4.335)

< 0.001

1.878 (1.361,2.593)

< 0.001

3.232 (2.398,4.357)

< 0.001

1.896 (1.375,2.615)

< 0.001

≤ 4.0

Differentiation grade

Poor

1.754 (1.294,2.377)

< 0.001

1.397 (0.948,2.059)

0.091

1.747 (1.290,2.368)

< 0.001

1.411 (0.958,2.080)

0.082

Well + moderate

Lauren’s histologic type

Diffuse

1.327 (0.983,1.792)

0.065

0.936 (0.615,1.426)

0.758

1.316 (0.975,1.777)

0.073

0.915 (0.602,1.389)

0.677

Intestinal

TNM stage

III + VI

4.867 (3.537,6.699)

< 0.001

3.215 (2.253,4.589)

< 0.001

4.870 (3.539,6.702)

< 0.001

3.205 (2.248,4.570)

< 0.001

I + II

Chemotherapy

No

0.336 (0.225,0.503)

< 0.001

0.648 (0.422,0.997)

0.049

0.335 (0.224,0.502)

< 0.001

0.643 (0.418,0.987)

0.044

Yes