Regular use of paracetamol and risk of liver cancer: a prospective cohort study

BMC Cancer

Table 2 The association between paracetamol use and risk of liver cancer

	Case/Person-years	Hazard Ratio [95% Confidence Interval]
	Case/Person-years	Crude model	Multivariable-adjusted model^a	Propensity score-weighted model^b
Non paracetamol user	456/4 304 030	1.00 [Reference]	1.00 [Reference]	1.00 [Reference]
Paracetamol user	171/1 229 448	1.41 [1.18, 1.68]	1.22 [1.01, 1.48]	1.28 [1.06, 1.54]

^aMultivariable adjusted model: adjusted for age, sex, UK Biobank assessment centers, race, smoking, alcohol consumption, physical activity, fruit and vegetable intake, meat intake, sleep time, BMI, concomitant comorbidities (hypertension, diabetes, hyperlipidemia, viral hepatitis, cirrhosis), current medication (multivitamin, mineral supplements, aspirin, ibuprofen, PPI, histamine-2 receptor antagonists, antihypertensive drugs, antidiabetic drugs, and statin), overall health rating, Long-standing illness, and family history of cancers
^bPropensity score–weighted model: propensity score was derived by multivariate logistic regression conditional on aforementioned covariates, and stabilized weight was calculated for each individual

ISSN: 1471-2407