Table 1 Baseline characteristics of participants by paracetamol use before and after weighting
From: Regular use of paracetamol and risk of liver cancer: a prospective cohort study
Before weighting | After weightinga | |||||
|---|---|---|---|---|---|---|
Non paracetamol user | Paracetamol user | SMD | Non paracetamol user | Paracetamol user | SMD | |
N | 361,226 | 103,018 | 71,398.71 | 71,398.71 | ||
Mean (SD) age, years | 56.99 (8.04) | 56.03 (8.30) | 0.118 | 56.48 (8.15) | 56.36 (8.27) | 0.014 |
Male, N (%) | 178,773 (49.5) | 36,695 (35.6) | 0.283 | 27,623.2 (38.7) | 27,623.2 (38.7) | < 0.001 |
White, N (%) | 342,623 (94.9) | 95,880 (93.1) | 0.075 | 66,900.8 (93.7) | 66,900.8 (93.7) | < 0.001 |
Smoking status, N (%) | 0.069 | < 0.001 | ||||
Current | 36,650 (10.1) | 12,422 (12.1) | 8258.7 (11.6) | 8258.7 (11.6) | ||
Previous | 122,436 (33.9) | 35,717 (34.7) | 24,751.2 (34.7) | 24,751.2 (34.7) | ||
Never | 202,140 (56.0) | 54,879 (53.3) | 38,388.8 (53.8) | 38,388.8 (53.8) | ||
Alcohol consumption, N (%) | 0.213 | < 0.001 | ||||
Daily or almost daily | 77,155 (21.4) | 16,871 (16.4) | 12,511.3 (17.5) | 12,511.3 (17.5) | ||
1–4 times a week | 181,284 (50.2) | 47,300 (45.9) | 33,680.3 (47.2) | 33,680.3 (47.2) | ||
One to three times a month | 38,481 (10.7) | 13,112 (12.7) | 8706.7 (12.2) | 8706.7 (12.2) | ||
Special occasions only/Never | 64,306 (17.8) | 25,735 (25.0) | 16,500.4 (23.1) | 16,500.4 (23.1) | ||
Physical activity, N (%) | 0.125 | < 0.001 | ||||
Low | 52,607 (14.6) | 17,572 (17.1) | 11,659.5 (16.3) | 11,659.5 (16.3) | ||
Moderate | 118,653 (32.8) | 32,815 (31.9) | 23,012.7 (32.2) | 23,012.7 (32.2) | ||
High | 120,927 (33.5) | 29,774 (28.9) | 21,374.4 (29.9) | 21,374.4 (29.9) | ||
Fruit and vegetable intake ≥ 5 portions per day, N (%) | 136,334 (37.7) | 37,978 (36.9) | 0.018 | 26,427.3 (37.0) | 26,427.3 (37.0) | < 0.001 |
Red and process meat intake, times per day, N (%) | 0.021 | < 0.001 | ||||
< 2 times per day | 54,505 (15.1) | 15,474 (15.0) | 10,805.8 (15.1) | 10,805.8 (15.1) | ||
2–3 times per day | 104,716 (29.0) | 28,974 (28.1) | 20,240.2 (28.3) | 20,240.2 (28.3) | ||
3–4 times per day | 54,733 (15.2) | 15,703 (15.2) | 10,914.2 (15.3) | 10,914.2 (15.3) | ||
> 4 times per day | 147,272 (40.8) | 42,867 (41.6) | 29,438.5 (41.2) | 29,438.5 (41.2) | ||
Mean (SD) sleep time, hours | 8.15 (1.12) | 8.06 (1.23) | 0.075 | 8.09 (1.19) | 8.09 (1.20) | < 0.001 |
Vitamin, N (%) | 50,416 (14.0) | 18,438 (17.9) | 0.108 | 11,983.3 (16.8) | 11,983.3 (16.8) | < 0.001 |
Mineral, N (%) | 73,361 (20.3) | 25,283 (24.5) | 0.102 | 16,652.0 (23.3) | 16,652.0 (23.3) | < 0.001 |
Mean (SD) body mass index | 27.24 (4.64) | 28.07 (5.17) | 0.168 | 27.83 (5.12) | 27.83 (4.98) | < 0.001 |
Health rating, N (%) | 0.371 | < 0.001 | ||||
Poor | 67,545 (18.7) | 10,337 (10.0) | 8239.8 (11.5) | 8239.8 (11.5) | ||
Fair | 213,278 (59.0) | 55,398 (53.8) | 40,048.2 (56.1) | 40,048.2 (56.1) | ||
Good | 68,861 (19.1) | 29,159 (28.3) | 18,678.2 (26.2) | 18,678.2 (26.2) | ||
Excellent | 11,542 (3.2) | 8124 (7.9) | 4432.5 (6.2) | 4432.5 (6.2) | ||
Long-standing illness, N (%) | 101,782 (28.2) | 40,299 (39.1) | 0.241 | 25,925.4 (36.3) | 25,925.4 (36.3) | < 0.001 |
Cancer history, N (%) | 125,244 (34.7) | 36,327 (35.3) | 0.012 | 25,092.3 (35.1) | 25,092.3 (35.1) | < 0.001 |
Hyperlipidemia, N (%) | 66,715 (18.5) | 18,916 (18.4) | 0.003 | 13,306.4 (18.6) | 13,306.4 (18.6) | < 0.001 |
Viral hepatitis, N (%) | 803 (0.2) | 212 (0.2) | 0.004 | 146.0 (0.2) | 146.0 (0.2) | < 0.001 |
Cirrhosis, N (%) | 327 (0.1) | 137 (0.1) | 0.013 | 86.7 (0.1) | 86.7 (0.1) | < 0.001 |
Hypertension, N (%) | 211,875 (58.7) | 59,036 (57.3) | 0.027 | 41,291.1 (57.8) | 41,291.1 (57.8) | < 0.001 |
Diabetes, N (%) | 18,662 (5.2) | 5389 (5.2) | 0.003 | 3776.7 (5.3) | 3776.7 (5.3) | < 0.001 |
Aspirin, N (%) | 50,662 (14.0) | 15,396 (14.9) | 0.026 | 10,445.4 (14.6) | 10,445.4 (14.6) | < 0.001 |
Ibuprofen, N (%) | 37,672 (10.4) | 33,205 (32.2) | 0.552 | 17,118.0 (24.0) | 17,118.0 (24.0) | < 0.001 |
PPI, N (%) | 30,677 (8.5) | 15,031 (14.6) | 0.192 | 9217.7 (12.9) | 9217.7 (12.9) | < 0.001 |
H2RA, N (%) | 5899 (1.6) | 3711 (3.6) | 0.124 | 2058.5 (2.9) | 2058.5 (2.9) | < 0.001 |
Antihypertensive drugs, N (%) | 72,613 (20.1%) | 21,647 (21.0%) | 0.023 | 15,046.8 (21.1) | 15,046.8 (21.1) | < 0.001 |
Antidiabetic drugs, N (%) | 13,666 (3.8) | 3755 (3.6) | 0.007 | 2678.9 (3.8) | 2678.9 (3.8) | < 0.001 |
Statin, N (%) | 58,761 (16.3) | 15,935 (15.5) | 0.022 | 11,376.1 (15.9) | 11,376.1 (15.9) | < 0.001 |