Fig. 1

Consensus clustering identified two stemness-based subtypes. (A-B) Delta area curves of consensus clustering; (C) Heatmap depicting consensus clustering solution (k = 2) for 26 stemness scores in LUAD;(D) Heat map of the distribution of 26 stemness scores in different stemness subtypes;(E) Distribution of mRNAsi in different stemness subtypes;(F) Kaplan–Meier overall survival curves for patients with lung adenocarcinoma between different stemness subtypes; (G) The distribution of Exclusion, TIDE and Dysfunction scores in the different subtypes of stemness; (H) Distributions of responder and non-responder to immunotherapy predicted by the TIDE algorithm among distinct stemness clusters. (***p < 0.001; **p < 0.01; *p < 0.05; ns: not significant)