Fig. 7

Gene enrichment analysis and downstream analysis of MYO5A in HNSC. A Heat maps of mRNA expression levels for high- and low-MYO5A-expressing in A-HNSC samples based on TCGA database. Principal component analysis was performed with the software R (4.2.1) and was visualized with “ggplot”. B The top 10 genes with the strongest association with MYO5A was listed. C-D Gene Set Enrichment Analysis (GSEA) of MYO5A were performed using the GSEA software (version 3.0). E Correlations were tested by Spearman’s correlation coefficient and five top KEGG categories were identified by R Statistical Software. F KEGG enrichment analysis of MYO5A were performed by R Statistical Software. G The circle graph of the DEGs of MYO5A in HNSC. H PPI network of MYO5A-associated genes was performed by STRING. DEG, Differentially expressed genes