Table 2 Stratified analyses for the association between TLS and OS of digestive system cancers by key factors
| Â | Subgroup | Number of studies | Pooled results HR(95%CI) | Heterogeneity test | |
|---|---|---|---|---|---|
I2(%) | p | ||||
Sample size |  ≥ 200 | 10 | 1.34 (1.31–1.61) | 25.51 | 0.21 |
 < 200 | 8 | 2.52 (1.99–3.20) | 22.85 | 0.25 | |
Metastasis | No | 8 | 1.82 (1.34–2.48) | 68.981 |  < 0.01 |
Yes | 8 | 1.86 (1.49–2.33) | 48.98 | 0.06 | |
NA | 2 | 1.44 (1.26–1.65) | 0 | 0.44 | |
Cut-off criteria | Presence vs. Absence | 8 | 1.69 (1.36–2.10) | 48.15 | 0.05 |
High vs. Low | 10 | 1.85 (1.45–2.35) | 64.64 |  < 0.01 | |
Types | ESCC | 3 | 1.76 (0.86–3.61) | 80.21 |  < 0.01 |
GC | 8 | 1.54 (1.33–1.79) | 28.80 | 0.20 | |
CRC | 1 | 2.42 (1.24–4.74) | NA | NA | |
HCC | 3 | 2.05 (1.08–3.88) | 70.89 | 0.03 | |
PC | 3 | 3.37 (1.09–10.37) | 71.76 | 0.03 | |