Table 3 Summary of treatment response in the study population: Comparison between patients treated with combination chemotherapy and immunotherapy versus chemotherapy alone

Chemotherapy plus ICI

Overall

Normal CRP

Elevated CRP

P

n = 105

n = 42

n = 63

Best Response (%)

CR

2 (2)

2 (4)

0 (0)

0.023

PR

60 (57)

28 (60)

32 (51)

SD

34 (32)

12 (29)

22(35)

PD

9 (9)

0 (0)

9 (14)

Objective Response Rate (%)

CR + PR

62 (59)

30 (71)

32 (51)

0.035

Disease Control Rate (%)

CR + PR + SD

96 (91)

42 (100)

54 (86)

0.015

Chemotherapy alone

Overall

Normal CRP

Elevated CRP

P

n = 140

n = 42

n = 98

Best Response (%)

CR

1 (1)

1 (2)

0 (0)

0.312

PR

59 (42)

20 (48)

39 (40)

SD

66 (47)

20 (48)

46 (47)

PD

14 (10)

1 (2)

13 (13)

Objective Response Rate (%)

CR + PR

60 (43)

21 (50)

39 (40)

0.322

Disease Control Rate (%)

CR + PR + SD

126 (90)

41 (98)

85 (87)

0.096