Table 3 Treatment-Related AEs
Adverse Event | RC48 |  | RC48 + ICIs |  | |||
|---|---|---|---|---|---|---|---|
All Grade | ≥ Grade3 | All Grade | ≥ Grade3 | ||||
Hematologic | Â | Â | Â | Â | |||
 Decreased white blood count | 11(55.0) | 2(10.0) |  | 14(56.0) | 3(12.0) |  | |
 Decreased neutrophil count | 11(55.0) | 2(10.0) |  | 13(52.0) | 3(12.0) |  | |
 Decreased platelet | 4(20.0) | 1(5.0) |  | 4(16.0) | 0 |  | |
 Anemia | 3(15.0) | 1(5.0) |  | 5(20.0) | 1(4.0) |  | |
 Increased ALT | 9(45.0) | 0 |  | 9(32.0) | 1(4.0) |  | |
 Increased AST | 9(45.0) | 0 |  | 8(32.0) | 1(4.0) |  | |
 Hyperbilirubinemia | 2(10.0) | 0 |  | 3(12.0) | 0 |  | |
 TSH elevation | 0 | 0 |  | 4(16.0) | 0 |  | |
Non-hematologic | Â | Â | Â | Â | Â | Â | |
 Fatigue | 12(60.0) | 0 |  | 14(56.0) | 0 |  | |
 Nausea or Vomiting | 5(25.0) | 0 |  | 4(16.0) | 0 |  | |
 Diarrhea | 3(15.0) | 0 |  | 3(12.0) | 1(4.0) |  | |
 Pyrexia | 3(15.0) | 0 |  | 4(16.0) | 0 |  | |
 Muscle pain/joint pain | 4(20.0) | 1(5.0) |  | 5(20.0) | 0 |  | |
 Hypoaesthesia | 11(55.0) | 2(10.0) |  | 14(56.0) | 2(8.0) |  | |
 Loss of appetite | 8(40.0) | 0 |  | 10(40.0) | 0 |  | |
 Alopecia | 13(65.0) | 0 |  | 15(60.0) | 0 |  | |
 Weight loss | 6(30.0) | 0 |  | 8(32.0) | 0 |  | |
 Rash | 2(10.0) | 0 |  | 4(16.0) | 0 |  | |
 Pruritus | 5(25.0) | 0 |  | 5(20.0) | 0 |  | |
 Pneumonitis | 0 | 0 |  | 2(8.0) | 1(4.0) |  | |
 Hypothyroidism | 0 | 0 |  | 4(16.0) | 0 |  | |
 Abdominal pain | 3(15.0) | 0 |  | 2(8.0) | 0 |  | |