High SNHG expression may predict a poor lung cancer prognosis based on a meta-analysis

Shen, Guo-yi; Huang, Rong-zhi; Yang, Shao-bin; Shen, Rong-qiang; Gao, Jian-li; Zhang, Yi

doi:10.1186/s12885-023-11706-4

BMC Cancer

Table 5 Regulation mechanism of SNHG involved in lung cancers

From: High SNHG expression may predict a poor lung cancer prognosis based on a meta-analysis

Lnc RNA	Expression level	Role	micro-RNA	Downstream targets or pathways	Cell line	Function (high snhg expression)	Reference
SNHG1	upregulated	oncogene	miR-101-3p	ROCK2	A549, A549/DDP,NCI-H520/DDP	reduce cisplatin sensitivity	Wei L 2019 [54]
SNHG1	upregulated	oncogene	miR-101-3p	Wnt/β-catenin signaling	A549, SPC-A1, H23 and NCI-H520	promote proliferation and cell cycle, suppress apoptosis	Cui Y 2017 [28]
SNHG1	upregulated	oncogene	miR-361-3p	FRAT1	BEAS-2B, H23, H1299	induce cell proliferation, migration,invasion, inhibit apoptosis	Li XM 2020 [42]
SNHG1	upregulated	oncogene	-	ZEB1	H-266 and SK-MES-1	promotes cell metastasis and invasion	Zhang HY 2017 [56]
GAS5	downregulated	tumor suppressor gene	miR-217	LHPP	H1299, A549, A549/DDP and H1299/DDP	reduced NSCLC/DDP cell migration, invasion and EMT process, reduces cisplatin-resistance	Yang XH 2021 [55]
SNHG3	downregulated	tumor suppressor gene	miR-890	-	HBE, A549, H1299, H1975	Inhibits the Proliferation, Migration and Invasion, and Promotes the Apoptosis	Kang BJ 2021 [40]
SNHG3	upregulated	oncogene	miR-1343-3p	NFIX	BEAS-2B, H1299, H358, A549 and H1975	promotes proliferation, migration and invasion and inhibits apoptosis	Zhao LJ 2021 [60]
SNHG3	upregulated	oncogene	-	IL‐6/JAK2/STAT3 pathway	CMT‐167, LLC, CMT‐170, and CMT‐181	promotes proliferation and migration	Shi JD 2019 [49]
SNHG3	upregulated	oncogene	miR-216a	ZEB1	A549, H322, H1299, GLC-82, and SPC-A1	induce Proliferation, Migration and Invasion, and suppress Apoptosis	Zhao SS 2020 [21]
SNHG4	upregulated	oncogene	miR-let-7e	KDM3A/p21 pathway	H1299, H1650, H1975, and SPCA1	promotes proliferation, migration and invasion and inhibits apoptosis	Wang F 2020 [50]
SNHG5	downregulated	tumor suppressor gene	miR-377	miR377/CASP1 axis	PC9 and A549	enhances gefitinib sensitivity	Wang ZX 2018 [63]
SNHG6	upregulated	oncogene	miR-485-3p	VPS45	BEAS-2B, H520, H596, H1650, H1703	induce cell growth, migration and invasion	Gao N 2020 [32]
SNHG6	upregulated	oncogene	miR-490-3p	RSF1, Bcl-2, bax, caspase-3	A549, H460 and H1299	Promotes Proliferation and Inhibits Apoptosis	Dong Z 2020 [30]
SNHG6	upregulated	oncogene	-	ETS1, MMP2, MMP9	A549, H226, H292, ANP973 and H1299	promotes proliferation and migration	Geng H 2020 [33]
SNHG6	upregulated	oncogene	miR-26a-5p	E2F7	A549, H1299, H460,HCC827, NCl-H358 and NCl-H1650	promotes cell proliferation, migration, invasion, and EMT and induces cell cycle progression	Liang R 2018 [44]
SNHG7	upregulated	oncogene	miR-449a	miR-449a/TGIF2 axis	BEAS-2B, A549 and H1299	contributes to cell proliferation, migration, invasion and EMT process	Pang LL 2019 [48]
SNHG7	upregulated	oncogene	miR-181a-5p	AKT/mTOR Signaling Pathway	A549, NCI-H1299	Accelerates Proliferation, Migration and Invasion	Li LP 2020 [41]
SNHG8	upregulated	oncogene	miR-542-3p	CCND1/CDK6	(A549, H23, SPC-A1, and NCI-H292	contributes to cell proliferation	Chen CH 2018 [24]
SNHG9	upregulated	oncogene	-	CAPRIN1	BEAS-2B, SK-MES-1, H460, A549 and H1299	promoted DDP resistance	Wang RX 2020 [51]
SNHG10	downregulated	tumor suppressor gene	miR-21	-	KLN 205, HCC827	increasing SNHG10 expression suppress cell proliferation	Liang M 2020 [64]
SNHG10	downregulated	tumor suppressor gene	miR-543	SIRT1	H1581 and H1703	increasing SNHG10 expression suppress cell proliferation	Zhang Z 2020 [65]
SNHG11	upregulated	oncogene	miR‐4436a	Wnt/β‐catenin signaling pathway	A549, H1299, H460	facilitated lung cancer cell prol iferation, migration, invasion, and EMT process while suppressed cell apoptosis	Liu SX 2019 [46]
SNHG12	upregulated	oncogene	-	HuR/PD-L1/USP8 axis	A549, SW1573, H1975, H1299	induce immune escape	Huang YS 2022 [37]
SNHG12	upregulated	oncogene	miR-218	Slug/ZEB2 signaling pathway	A549, H1299	Accelerates Migration and EMT process	Wang Y 2019 [20]
SNHG13	upregulated	oncogene	miR-758-3p	-	SPC-A1 and NCI-H1299	promotes tumor NSCLC cell migration and invasion	Wang S 2018 [52]
SNHG13	upregulated	oncogene	-	p21	A549, H1299 and H358	contributes to cell proliferation, migration, invasion and EMT process	Guo LF 2019 [34]
SNHG13	upregulated	oncogene	miR-1225-3p	ErbB2	A549, SPCA1, H1299 and H1975	Enhanced Migration and Invasion	Huang YF 2021 [38]
SNHG13	upregulated	oncogene	-	HMGA2	SPCA1 and A549	promotes invasion	Zhang NN 2021 [57]
SNHG14	upregulated	oncogene	miR-382-5p	SPIN1	H1299, A549	induce Proliferation, Migration and Invasion, and suppress Apoptosis	Chen XL 2020 [25]
SNHG14	upregulated	oncogene	miR-340	-	16HBE, A549, NCI-H1975, NCI-H1299, SK-MES-1	induce Proliferation and suppress Apoptosis	Zhang ZH 2018 [58]
SNHG15	upregulated	oncogene	miR-211-3p	ZNF217	HBEC3, H358, H1299, H23 and A549	Promoted Proliferation and Migration	Ma XR 2019 [47]
SNHG15	upregulated	oncogene	miR-211-3p	-	H1799 and A549	promotes proliferation and migration	Cui HX 2018 [27]
SNHG15	upregulated	oncogene	miR-486	CDK14	A549, H460, SK-MES-1, and Calu-3	induce Proliferation, Migration and Invasion, and suppress Apoptosis	Jin B 2018 [39]
SNHG16	upregulated	oncogene	-	ALDH2, Bax, Bcl-2	A549 and SK-LU-1	cell proliferation	Li Y 2022 [43]
SNHG16	upregulated	oncogene	miR-146a	MUC5AC	A549, NCI-H292, NCI-H460, and NCI-H1703	promotes NSCLC cell proliferation, migration and invasion	Han W 2018 [36]
SNHG17	upregulated	oncogene	miR-193a-5p	NETO2	BEAS-2B, A549, H1299, H1650, H1975 and CALU-3	facilitate migration, invasion, proliferation and EMT	Zhang ZW 2021 [59]
SNHG18	upregulated	oncogene	miR-211-5p	miR-211-5p/BRD4 axis	A549, H1299, H23, H460, and H1792	promotes NSCLC cell proliferation, migration and invasion	Fan HJ 2021 [31]
SNHG20	upregulated	oncogene	miR-154	ZEB2 and RUNX2	A549, H322, H1299, GLC-82, and SPC-A1	promotes proliferation, migration and invasion, and suppresses apoptosis	Jin LL 2019 [45]
SNHG20	upregulated	oncogene	-	P21	PC9, SPC-A1, NCIH1975, H1299 and A549	promotes cell proliferation and migration	Chen ZY 2017 [26]
SNHG20	upregulated	oncogene	miR-342	DDX49	BEAS-2B, A549 and H1299	promoted proliferation, invasion and inhibited cell apoptosis	Wang XL 2020 [53]

ROCK2 Rho-associated coiled-coil containing protein kinase 2, FRAT1 FRAT Regulator Of WNT Signaling Pathway 1, ZEB1 Zinc finger E-box-binding homeobox protein 1, LHPP Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase, NFIX Nuclear Factor I X, JAK2 Janus kinase 2, KDM3A Lysine Demethylase 3A, CASP1 Caspase 1, VPS45 Vacuolar Protein Sorting 45 Homolog, RSF1 Remodeling And Spacing Factor 1, MMP2 Matrix metalloproteinase 2, MMP9 Matrix metalloproteinase 9, E2F7 E2F Transcription Factor 7, TGIF2 TGFB Induced Factor Homeobox 2, CCND1 Cyclin D1, CDK6 Cyclin-dependent kinase 6, SIRT1 Sirtuin 1, ErbB2 Human epidermal growth factor receptor 2, HMGA2 High Mobility Group AT-Hook 2, SPIN1 Spindlin 1, ZNF217 Zinc Finger Protein 217, CDK14 Cyclin-dependent kinase 14, ALDH2 Acetaldehyde dehydrogenase 2, MUC5AC Mucin 5AC, NETO2 Neuropilin And Tolloid Like 2, ZEB2 Zinc finger E-box binding homeobox (Zeb) 2, RUNX2 Runt-related transcription factor 2, DDX49 DEAD-Box Helicase 49

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ISSN: 1471-2407

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