Table 1 Summary of the five tasks of the study

Task 1-

Clinical Study

1–48

Eligibility check and patient enrollment (WP1), collection of baseline patient-, disease- and treatment-related data (WP2), follow-up and collection of patient-, disease and treatment-related data (WP3)

Task 2-

Imaging/Radiomic Study

1–60

Collection of qualitative and semi-quantitative CT image metrics (WP4), collection of qualitative and semi-quantitative 18FDG-PET/CT image metrics (WP5), radiomic analysis on CT and [18 F]-FDG-PET/CT images (WP6)

Task 3-

Gene Expression Study

1–48

Sample collection and storage of FFPE samples from either the resected tumor or tissue biopsy (WP7), gene expression profiling through the NGS-based assay OIRRA (WP8)

Task 4-

Proteomic Study

1–48

Sample collection and storage of FFPE samples from either the resected tumor or tissue biopsy (WP9), proteomics analysis through the PATH-MS method (WP10)

Task 5-

Integrative Model Building

48–60

Data cleaning, exploratory data analysis, regularization (WP11), model training and validation (WP12)