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Table 2 Univariate and multivariate analysis of predictors selected by Cox regression model in the training set

From: Construction and validation of a nomogram to predict the overall survival of small cell lung cancer: a multicenter retrospective study in Shandong province, China

Variables

Univariate analysis

 

Multivariate analysis

HR (95% CI)

P Value

 

HR (95% CI)

P Value

Sex

     

 Male

Reference

  

Reference

 

 Female

0.839 (0.739–0.952)

0.006

 

0.851 (0.728–0.995)

0.043

Age

     

 ≤ 45

Reference

  

Reference

 

 46–60

1.423 (1.122–1.805)

0.004

 

1.397 (1.100-1.774)

0.006

 61–75

1.723 (1.361–2.182)

< 0.001

 

1.493 (1.175–1.896)

0.001

 > 75

2.378 (1.768–3.198)

< 0.001

 

1.861 (1.376–2.516)

< 0.001

Region

     

 Eastern

Reference

  

Reference

 

 Southern

1.261 (1.011–1.572)

0.039

 

1.304 (1.045–1.628)

0.019

 Western

0.685 (0.583–0.804)

< 0.001

 

0.726 (0.616–0.855)

< 0.001

 Northern

0.909 (0.785–1.052)

0.199

 

0.926 (0.799–1.073)

0.306

Hospital

     

 Specialized

Reference

    

 General

1.032 (0.884–1.204)

0.693

   

Health insurance

     

 Urban employees’ basic medical insurance

Reference

    

 Urban residents’ basic medical insurance

0.986 (0.810–1.200)

0.885

   

 New rural cooperative medical scheme

0.972 (0.853–1.108)

0.673

   

 Self-pay

1.069 (0.794–1.440)

0.660

   

 Other

0.687 (0.409–1.154)

0.156

   

Smoke

     

 No

Reference

  

Reference

 

 Yes

1.159 (1.034–1.298)

0.011

 

1.025 (0.89–1.182)

0.729

Alcohol use

     

 No

Reference

    

 Yes

1.074 (0.955–1.208)

0.231

   

TNM Stage

     

 I

Reference

  

Reference

 

 II

1.152 (0.830–1.597)

0.398

 

1.116 (0.797–1.561)

0.523

 III

1.468 (1.108–1.944)

0.007

 

1.471 (1.094–1.978)

0.011

 IV

2.142 (1.620–2.832)

< 0.001

 

1.977 (1.469–2.66)

< 0.001

Surgery

     

 No

Reference

  

Reference

 

 Yes

0.563 (0.439–0.721)

< 0.001

 

0.675 (0.519–0.879)

0.003

Chemotherapy

     

 No

Reference

  

Reference

 

 Yes

0.674 (0.589–0.770)

< 0.001

 

0.707 (0.616–0.813)

< 0.001

Radiotherapy

     

 No

Reference

  

Reference

 

 Yes

0.775 (0.681–0.882)

< 0.001

 

0.803 (0.702–0.917)

< 0.001

  1. Notes: HR, hazard ratio; Eastern, Southern, Western, and Northern represent respectively Eastern of Shandong, Southern of Shandong, Western of Shandong, and Northern of Shandong; Specialized, General represent respectively specialized tumor hospitals and general hospitals