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Fig. 6 | BMC Cancer

Fig. 6

From: RGD-p21Ras-scFv expressed prokaryotically on a pilot scale inhibits ras-driven colorectal cancer growth by blocking p21Ras-GTP

Fig. 6

RGD-p21Ras-scFv inhibited the growth of xenografts in nude mice. (A, D) All the nude mice were weighed and divided into the following five groups: PBS, RGD, RGD-p21Ras-scFv, DMSO and K-Ras(G12C) inhibitor group. The tumor growth curves were drawn according to the tumor sizes. The tumor volume growth was inhibited by the RGD-p21Ras-scFv. (B, E) RGD-p21Ras-scFv treatment group had the lowest tumor weight compared to the other groups. (C, F) Tumor tissues from each group were dissected and examined by general observation. (G, H) IHC showed there were less Ki67-positive cells in the RGD-p21Ras-scFv treatment group. Ki67 index (PI) was calculated and scored from the number of Ki67-positive cells to the total number of tumor cells, Mean ± SD. *P < 0.05, **P < 0.01. (I) After 24 days of treatment, RGD-p21Ras-scFv was only presented in xenograft tumor tissues rather than in any other major organs by IHC analysis

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BMC Cancer

ISSN: 1471-2407

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