Skip to main content
Fig. 3 | BMC Cancer

Fig. 3

From: RGD-p21Ras-scFv expressed prokaryotically on a pilot scale inhibits ras-driven colorectal cancer growth by blocking p21Ras-GTP

Fig. 3

RGD-p21Ras-scFv significantly inhibits the growth of Ras-derived tumor cell lines. Eleven Ras-derived-associated tumor cell lines and one normal epithelial cell lines were co-cultured with RGD-p21Ras-scFv, PBS, and RGD peptide in 96-well plates for 24, 48, and 72 h, and then cellular activity was assayed using the CCK-8 time. rgd-p21Ras-scFv inhibited the growth of the incorporated Ras-derived tumor cells but had no normal colon epithelial cell effects. (A) CCD841; (B) A549, (C) AGS, (D) AsPC-1, (E) HePG-2, (F) MDB-MA-321, (G) MIApaca-2, (H) PANC- 1, (I) U251, (J) SW480, (K) HT29 and (L) SW480 Data are expressed as the mean of three independent experiments expressed, Mean ± SD. *p < 0.05; **p < 0.01, ***p < 0.001, ****p < 0.0001

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us