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Fig. 2 | BMC Cancer

Fig. 2

From: RGD-p21Ras-scFv expressed prokaryotically on a pilot scale inhibits ras-driven colorectal cancer growth by blocking p21Ras-GTP

Fig. 2

RGD-p21Ras-scFv could bind stably to K-p21Ras, H-p21Ras and N-p21Ras proteins. (A) RGD-p21Ras-scFv was immunoreactive with K-p21Ras, H-p21Ras and N-p21Ras at 1:800 by ELISA. (B, C, D) The molecular docking model of RGD-p21Ras-scFv to K-p21Ras, H-p21Ras and N-p21Ras proteins, The RGD-p21Ras-scFv binds to p21Ras through hydrogen bonding and salt bridges et al. (E-P) Molecular dynamics simulated the interaction and stability of RGD-p21Ras-scFv upon binding to p21Ras. The complexes formed by RGD-p21Ras-scFv with K-p21Ras, H-p21Ras and N-p21Ras fluctuated very little and were highly stable during the simulation process, and the graphs demonstrated RMSF; RMSD; Rg; and the number of hydrogen bonding from left to right, respectively

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BMC Cancer

ISSN: 1471-2407

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