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Table 4 Univariate and multivariate analyses for overall survival (OS)

From: “Moderate” adjuvant chemotherapy-induced leukopenia is beneficial for survival of patients with early breast cancer: a retrospective study

Characteristics

Univariate Analysis

Multivariate Cox Regression Analysis

HRa, 95%CI

P-value

HRa, 95%CI

P-value

Menstrual Status

 premenopausal

    

 postmenopausal

2.31[1.14,4.69]

0.021

2.39[1.16,4.91]

0.018

BMI

 ≤ 25

    

 > 25

1.04[0.45,2.41]

0.934

  

HR b Status

 Negative

    

 Positive

1.92[0.83,4.47]

0.128

  

HER2 Status

 Negative

    

 Positive

0.90[0.44,1.85]

0.769

  

Ki-67 Indexa

 ≤ 15%

    

 > 15%

1.38[0.57,3.38]

0.478

  

T Stageb

 T1

    

 T2

1.00[[0.46,2.19]

1.000

  

 T3

2.34[0.73,7.46]

0.152

  

 N Stageb

 N0

    

 N1

4.12[1.15,14.77]

0.030

3.85[1.06,14.01]

0.041

 N2

3.86[0.97,15.43]

0.056

3.41[0.82,14.16]

0.091

 N3

8.85[2.47,31.74]

< 0.001

6.50[1.72,24.60]

0.006

LVI

 No

    

 Yes

2.64[1.22,5.74]

0.014

1.85[0.81,4.19]

0.143

CIL

 0/I

    

 II/III

0.46[0.19,1.10]

0.082

0.39[0.16,0.95]

0.037

 IV

0.23[0.07,0.73]

0.012

0.18[0.06,0.59]

0.004

  1. Abbreviations: HR Hazard ratio, CI Confidence interval, BMI Body mass index, HR Hormone receptor, HER-2 Human epidermal growth factor receptor-2, LVI Lymphatic vessel invaded, CIL Chemotherapy-induced leukopenia
  2. aIndicating DNA synthetic activity as measured using immunocytochemistry
  3. bAccording to the 7th edition of the UICC/AJCC staging system