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Table 1 The relationship between CIL grade and other clinicopathological features

From: “Moderate” adjuvant chemotherapy-induced leukopenia is beneficial for survival of patients with early breast cancer: a retrospective study

Baseline Characteristics

Total(n,%)

CIL Grade(n,%)

P-value

0/I

II/III

IV

Age at diagnosis

0.215

 ≤ 46 years

224(50.68)

20(43.48)

145(55.77)

59(43.38)

 

 > 46 years

218(49.32)

26(56.52)

115(44.23)

77(56.62)

 

BMI

0.860

 < 25

346(78.28)

33(71.73)

208(80.00)

105(77.21)

 

 ≥ 25

96(21.72)

13(28.26)

52(20.00)

31(22.79)

 

Menstrual Status

0.185

 premenopausal

280(63.35)

31(67.39)

169(65.00)

80(58.82)

 

 postmenopausal

162(36.65)

15(32.61)

91(35.00)

56(41.18)

 

HR Status

0.668

 Negative

162(36.65)

10(21.74)

105(40.38)

47(34.56)

 

 Positive

280(63.35)

36(78.26)

155(59.62)

89(65.44)

 

HER2 Status

0.181

 Negative

260(58.82)

32(69.57)

152(58.46)

76(55.88)

 

 Positive

182(41.18)

14(30.43)

108(41.54)

60(44.12)

 

KI67 Indexa

0.913

 ≤ 15%

103(23.30)

13(28.26)

56(21.54)

34(25.00)

 

 > 15%

339(76.70)

33(71.73)

204(78.46)

102(75.00)

 

Pathological Grade

0.982

 1 + 2

220(49.77)

27(58.69)

122(46.92)

71(52.21)

 

 3

222(50.23)

19(41.30)

138(53.08)

65(47.79)

 

T Stageb

< 0.01

 T1

152(34.39)

12(26.09)

83(31.92)

57(41.91)

 

 T2

261(59.05)

30(65.22)

157(60.38)

74(54.41)

 

 T3

29(6.56)

4(8.70)

20(7.69)

5(3.68)

 

N Stageb

< 0.01

 N0

150(33.94)

16(34.78)

87(33.46)

47(34.56)

 

 N1

141(31.90)

12(26.09)

90(34.62)

39(28.68)

 

 N2

81(18.33)

11(23.91)

39(15.00)

31(22.79)

 

 N3

70(15.83)

7(15.22)

44(16.92)

19(13.97)

 

LVI

0.540

 No

225(50.90)

21(45.65)

133(51.15)

71(52.21)

 

 Yes

217(49.10)

25(54.35)

127(48.85)

65(47.79)

 

Chemotherapy

< 0.01

 TE or TEC

69(15.61)

17(36.96)

24(9.23)

28(20.59)

 

 FEC-T

59(13.35)

8(17.39)

33(12.69)

18(13.24)

 

 AC-T

314(71.04)

21(45.65)

203(78.08)

90(66.18)

 
  1. Abbreviations: CIL Chemotherapy-induced leukopenia, BMI Body mass index, HR Hormone receptor, HER-2 Human epidermal growth factor receptor-2, LVI Lymphatic vessel invaded, TE Taxanes combined with Anthracycline, TEC Taxanes, Anthracycline combined with cyclophosphamide, FEC-T 5-fluorouracil, Anthracycline combined with cyclophosphamide followed by Taxanes, AC-T Taxanes combined with cyclophosphamide followed by Taxanes
  2. aIndicating DNA synthetic activity as measured using immunocytochemistry
  3. bAccording to the 7th edition of the UICC/AJCC staging system